FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048662026> ?p ?o ?g. }

• W2048662026 endingPage "31" @default.
• W2048662026 startingPage "22" @default.
• W2048662026 abstract "Gastrointestinal dysmotility is one of the nonmotor symptoms of Parkinson's disease (PD). Gastroparesis and upregulated β-adrenoceptors (β-ARs) have been reported in rats with bilateral microinjection of 6-hydroxydopamine (6-OHDA) in the substantia nigra, but the underlying mechanism is unclear. The aim of the current study is to investigate the role of β-ARs in gastroparesis in 6-OHDA rats. Gastric motility was studied through strain gauge measurement. Immunofluorescence, real-time reverse transcription-polymerase chain reaction and Western blotting were performed to examine the expression of β-ARs. Norepinephrine (NE) inhibited gastric motility in a dose-dependent fashion in both control and 6-OHDA rats, but much stronger adrenergic reactivity was observed in the 6-OHDA rats. The inhibition of gastric motility by NE in both control and 6-OHDA rats was not affected by tetrodotoxin, a neural sodium channel blocker. Blocking β1-AR or β2-AR did not affect the inhibition of strip contraction by NE in control rats, but β1-AR blockage obviously enhanced the half maximal inhibitory concentration value of NE in 6-OHDA rats. Selective inhibition of β3-AR blocked the effect of NE significantly in both control and 6-OHDA rats. The protein expression of β1-AR, but not β2-AR and β3-AR in gastric muscularis externa was increased significantly in 6-OHDA rats. In conclusion, β3-AR involves the regulation of gastric motility in control rats, whereas the upregulation of β1-AR is responsible for enhanced NE reactivity in 6-OHDA rats and therefore is involved in the formation of gastroparesis. The effect of both β1-AR and β3-AR on gastric motility is independent of the enteric nervous system. Gastrointestinal dysmotility is one of the nonmotor symptoms of Parkinson's disease (PD). Gastroparesis and upregulated β-adrenoceptors (β-ARs) have been reported in rats with bilateral microinjection of 6-hydroxydopamine (6-OHDA) in the substantia nigra, but the underlying mechanism is unclear. The aim of the current study is to investigate the role of β-ARs in gastroparesis in 6-OHDA rats. Gastric motility was studied through strain gauge measurement. Immunofluorescence, real-time reverse transcription-polymerase chain reaction and Western blotting were performed to examine the expression of β-ARs. Norepinephrine (NE) inhibited gastric motility in a dose-dependent fashion in both control and 6-OHDA rats, but much stronger adrenergic reactivity was observed in the 6-OHDA rats. The inhibition of gastric motility by NE in both control and 6-OHDA rats was not affected by tetrodotoxin, a neural sodium channel blocker. Blocking β1-AR or β2-AR did not affect the inhibition of strip contraction by NE in control rats, but β1-AR blockage obviously enhanced the half maximal inhibitory concentration value of NE in 6-OHDA rats. Selective inhibition of β3-AR blocked the effect of NE significantly in both control and 6-OHDA rats. The protein expression of β1-AR, but not β2-AR and β3-AR in gastric muscularis externa was increased significantly in 6-OHDA rats. In conclusion, β3-AR involves the regulation of gastric motility in control rats, whereas the upregulation of β1-AR is responsible for enhanced NE reactivity in 6-OHDA rats and therefore is involved in the formation of gastroparesis. The effect of both β1-AR and β3-AR on gastric motility is independent of the enteric nervous system." @default.
• W2048662026 created "2016-06-24" @default.
• W2048662026 creator A5010776860 @default.
• W2048662026 creator A5030600214 @default.
• W2048662026 creator A5031321801 @default.
• W2048662026 creator A5047903038 @default.
• W2048662026 creator A5053897768 @default.
• W2048662026 creator A5054228072 @default.
• W2048662026 creator A5060807743 @default.
• W2048662026 creator A5066704146 @default.
• W2048662026 creator A5074748619 @default.
• W2048662026 date "2014-07-01" @default.
• W2048662026 modified "2023-10-01" @default.
• W2048662026 title "Upregulation of β1-adrenoceptors is involved in the formation of gastric dysmotility in the 6-hydroxydopamine rat model of Parkinson's disease" @default.
• W2048662026 cites W1565178587 @default.
• W2048662026 cites W1886198396 @default.
• W2048662026 cites W1967300240 @default.
• W2048662026 cites W1975035813 @default.
• W2048662026 cites W1983080964 @default.
• W2048662026 cites W1991349201 @default.
• W2048662026 cites W1991504761 @default.
• W2048662026 cites W1997956840 @default.
• W2048662026 cites W2000972310 @default.
• W2048662026 cites W2006745000 @default.
• W2048662026 cites W2008501231 @default.
• W2048662026 cites W2012286700 @default.
• W2048662026 cites W2013652223 @default.
• W2048662026 cites W2024249375 @default.
• W2048662026 cites W2034151625 @default.
• W2048662026 cites W2054121399 @default.
• W2048662026 cites W2056657856 @default.
• W2048662026 cites W2059261801 @default.
• W2048662026 cites W2059388126 @default.
• W2048662026 cites W2065438224 @default.
• W2048662026 cites W2067313980 @default.
• W2048662026 cites W2069540511 @default.
• W2048662026 cites W2077886817 @default.
• W2048662026 cites W2086130988 @default.
• W2048662026 cites W2090609711 @default.
• W2048662026 cites W2126308606 @default.
• W2048662026 cites W2129181278 @default.
• W2048662026 cites W2135426811 @default.
• W2048662026 cites W2135609089 @default.
• W2048662026 cites W2140602957 @default.
• W2048662026 cites W2150610663 @default.
• W2048662026 cites W2164355842 @default.
• W2048662026 cites W2168440203 @default.
• W2048662026 doi "https://doi.org/10.1016/j.trsl.2014.01.001" @default.
• W2048662026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24467967" @default.
• W2048662026 hasPublicationYear "2014" @default.
• W2048662026 type Work @default.
• W2048662026 sameAs 2048662026 @default.
• W2048662026 citedByCount "16" @default.
• W2048662026 countsByYear W20486620262015 @default.
• W2048662026 countsByYear W20486620262016 @default.
• W2048662026 countsByYear W20486620262017 @default.
• W2048662026 countsByYear W20486620262020 @default.
• W2048662026 countsByYear W20486620262021 @default.
• W2048662026 countsByYear W20486620262022 @default.
• W2048662026 countsByYear W20486620262023 @default.
• W2048662026 crossrefType "journal-article" @default.
• W2048662026 hasAuthorship W2048662026A5010776860 @default.
• W2048662026 hasAuthorship W2048662026A5030600214 @default.
• W2048662026 hasAuthorship W2048662026A5031321801 @default.
• W2048662026 hasAuthorship W2048662026A5047903038 @default.
• W2048662026 hasAuthorship W2048662026A5053897768 @default.
• W2048662026 hasAuthorship W2048662026A5054228072 @default.
• W2048662026 hasAuthorship W2048662026A5060807743 @default.
• W2048662026 hasAuthorship W2048662026A5066704146 @default.
• W2048662026 hasAuthorship W2048662026A5074748619 @default.
• W2048662026 hasConcept C104317684 @default.
• W2048662026 hasConcept C126322002 @default.
• W2048662026 hasConcept C127561419 @default.
• W2048662026 hasConcept C134018914 @default.
• W2048662026 hasConcept C137183658 @default.
• W2048662026 hasConcept C185592680 @default.
• W2048662026 hasConcept C2777288102 @default.
• W2048662026 hasConcept C2778769438 @default.
• W2048662026 hasConcept C2779134260 @default.
• W2048662026 hasConcept C2779422922 @default.
• W2048662026 hasConcept C2779734285 @default.
• W2048662026 hasConcept C2780938664 @default.
• W2048662026 hasConcept C2911016594 @default.
• W2048662026 hasConcept C3020479747 @default.
• W2048662026 hasConcept C513476851 @default.
• W2048662026 hasConcept C55493867 @default.
• W2048662026 hasConcept C58207958 @default.
• W2048662026 hasConcept C71924100 @default.
• W2048662026 hasConcept C86803240 @default.
• W2048662026 hasConcept C95444343 @default.
• W2048662026 hasConceptScore W2048662026C104317684 @default.
• W2048662026 hasConceptScore W2048662026C126322002 @default.
• W2048662026 hasConceptScore W2048662026C127561419 @default.
• W2048662026 hasConceptScore W2048662026C134018914 @default.
• W2048662026 hasConceptScore W2048662026C137183658 @default.
• W2048662026 hasConceptScore W2048662026C185592680 @default.
• W2048662026 hasConceptScore W2048662026C2777288102 @default.
• W2048662026 hasConceptScore W2048662026C2778769438 @default.

• next