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- W2048662893 abstract "A key player in mitotic progression is a cell-cycle-regulated ubiquitin–protein ligase complex known as the anaphase-promoting complex or cyclosome (APC/C). The APC/C is part of the machinery that promotes the metaphase–anaphase transition by mediating the ubiquitin-dependent destruction of anaphase inhibitors and initiates exit from mitosis by degrading mitotic cyclins. This review describes the known components and substrates of the mitotic ubiquitination machinery and discusses how a new subfamily of proteins that contain the WD40 repeat (the Fizzy/Cdc20p family) might activate the APC/C to allow temporal differences in substrate ubiquitination during progression through mitosis." @default.
- W2048662893 created "2016-06-24" @default.
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- W2048662893 date "1998-06-01" @default.
- W2048662893 modified "2023-10-17" @default.
- W2048662893 title "Proteolytic ratchets that control progression through mitosis" @default.
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- W2048662893 doi "https://doi.org/10.1016/s0962-8924(98)01268-9" @default.
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