Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048663988> ?p ?o ?g. }
- W2048663988 endingPage "705" @default.
- W2048663988 startingPage "698" @default.
- W2048663988 abstract "Cerebrospinal fluid (CSF) is routinely used for diagnosing and monitoring neurological diseases. The CSF proteins used so far for diagnostic purposes (except for those associated with whole cells) are soluble. Here, we show that human CSF contains specific membrane particles that carry prominin-1/CD133, a neural stem cell marker implicated in brain tumors, notably glioblastoma. Differential and equilibrium centrifugation and detergent solubility analyses showed that these membrane particles were similar in physical properties and microdomain organization to small membrane vesicles previously shown to be released from neural stem cells in the mouse embryo. The levels of membrane particle-associated prominin-1/CD133 declined during childhood and remained constant thereafter, with a remarkably narrow range in healthy adults. Glioblastoma patients showed elevated levels of membrane particle-associated prominin-1/CD133, which decreased dramatically in the final stage of the disease. Hence, analysis of CSF for membrane particles carrying the somatic stem cell marker prominin-1/CD133 offers a novel approach for studying human central nervous system disease." @default.
- W2048663988 created "2016-06-24" @default.
- W2048663988 creator A5003141905 @default.
- W2048663988 creator A5006069097 @default.
- W2048663988 creator A5014249857 @default.
- W2048663988 creator A5015793337 @default.
- W2048663988 creator A5019226669 @default.
- W2048663988 creator A5022392635 @default.
- W2048663988 creator A5029249438 @default.
- W2048663988 creator A5031918859 @default.
- W2048663988 creator A5034516179 @default.
- W2048663988 creator A5036198382 @default.
- W2048663988 creator A5048401390 @default.
- W2048663988 creator A5050134970 @default.
- W2048663988 creator A5052590367 @default.
- W2048663988 creator A5054050972 @default.
- W2048663988 creator A5059994888 @default.
- W2048663988 creator A5061975653 @default.
- W2048663988 creator A5064568092 @default.
- W2048663988 creator A5068910840 @default.
- W2048663988 creator A5072500215 @default.
- W2048663988 creator A5081553492 @default.
- W2048663988 creator A5090717297 @default.
- W2048663988 date "2007-12-20" @default.
- W2048663988 modified "2023-09-26" @default.
- W2048663988 title "The Stem Cell Marker Prominin-1/CD133 on Membrane Particles in Human Cerebrospinal Fluid Offers Novel Approaches for Studying Central Nervous System Disease" @default.
- W2048663988 cites W116758555 @default.
- W2048663988 cites W1237494586 @default.
- W2048663988 cites W133253872 @default.
- W2048663988 cites W1564861448 @default.
- W2048663988 cites W1762620449 @default.
- W2048663988 cites W1964136810 @default.
- W2048663988 cites W1966009759 @default.
- W2048663988 cites W1970796584 @default.
- W2048663988 cites W1972193901 @default.
- W2048663988 cites W1977613047 @default.
- W2048663988 cites W1979964850 @default.
- W2048663988 cites W1980940171 @default.
- W2048663988 cites W1982765555 @default.
- W2048663988 cites W1986815130 @default.
- W2048663988 cites W1987031126 @default.
- W2048663988 cites W1989249682 @default.
- W2048663988 cites W1989958716 @default.
- W2048663988 cites W1992618202 @default.
- W2048663988 cites W2001544973 @default.
- W2048663988 cites W2024320298 @default.
- W2048663988 cites W2029231546 @default.
- W2048663988 cites W2035642678 @default.
- W2048663988 cites W2044892825 @default.
- W2048663988 cites W2048887344 @default.
- W2048663988 cites W2051055358 @default.
- W2048663988 cites W2051893774 @default.
- W2048663988 cites W2054637102 @default.
- W2048663988 cites W2060551076 @default.
- W2048663988 cites W2065737043 @default.
- W2048663988 cites W2066865589 @default.
- W2048663988 cites W2079356804 @default.
- W2048663988 cites W2085204161 @default.
- W2048663988 cites W2085287710 @default.
- W2048663988 cites W2086833393 @default.
- W2048663988 cites W2095789123 @default.
- W2048663988 cites W2109214564 @default.
- W2048663988 cites W2111428621 @default.
- W2048663988 cites W2113544773 @default.
- W2048663988 cites W2117198101 @default.
- W2048663988 cites W2118933841 @default.
- W2048663988 cites W2123509170 @default.
- W2048663988 cites W2126932298 @default.
- W2048663988 cites W2127792983 @default.
- W2048663988 cites W2129062330 @default.
- W2048663988 cites W2130923575 @default.
- W2048663988 cites W2137703931 @default.
- W2048663988 cites W2147905750 @default.
- W2048663988 cites W2148353419 @default.
- W2048663988 cites W2156232698 @default.
- W2048663988 cites W2158804607 @default.
- W2048663988 cites W2159726491 @default.
- W2048663988 cites W2162017151 @default.
- W2048663988 cites W2166813889 @default.
- W2048663988 cites W2167831294 @default.
- W2048663988 cites W2171672500 @default.
- W2048663988 cites W4253992140 @default.
- W2048663988 doi "https://doi.org/10.1634/stemcells.2007-0639" @default.
- W2048663988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18096722" @default.
- W2048663988 hasPublicationYear "2007" @default.
- W2048663988 type Work @default.
- W2048663988 sameAs 2048663988 @default.
- W2048663988 citedByCount "81" @default.
- W2048663988 countsByYear W20486639882012 @default.
- W2048663988 countsByYear W20486639882013 @default.
- W2048663988 countsByYear W20486639882014 @default.
- W2048663988 countsByYear W20486639882015 @default.
- W2048663988 countsByYear W20486639882016 @default.
- W2048663988 countsByYear W20486639882017 @default.
- W2048663988 countsByYear W20486639882018 @default.
- W2048663988 countsByYear W20486639882019 @default.
- W2048663988 countsByYear W20486639882020 @default.
- W2048663988 countsByYear W20486639882021 @default.