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- W2048667068 abstract "DNA-dependent DNA polymerases have been studied during chick embryo muscle differentiation in vitro. The total activity, extracted at both low and high ionic strengths, does not change throughout the differentiative process, although DNA synthesis stops at the moment of fusion. Analyses by glycerol gradient centrifugation of the extracts at low and high ionic strengths show two major DNA polymerase forms, one sedimenting at 7.5 S and another at 3-4 S. Both enzymes are present in similar amounts in duplicating myoblasts and in post-mitotic myotubes. These data suggest that the arrest of DNA synthesis which accompanies myoblast differentiation is not dependent on the disappearance or decrease of the major DNA polymerase activities described." @default.
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- W2048667068 date "1977-06-01" @default.
- W2048667068 modified "2023-09-23" @default.
- W2048667068 title "DNA replication during muscle cell differentiation: identification of multiple DNA-dependent DNA polymerases" @default.
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- W2048667068 doi "https://doi.org/10.1016/0045-6039(77)90040-9" @default.
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