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• W2048673295 abstract "Significant emphasis has recently been placed on the characterization of the human cancer genome. This effort has been assisted by the development of new DNA sequencing technologies that allow the genomes of individual tumors to be analyzed in much greater detail. However, the genetic complexity of human cancer has complicated the identification of driver mutations among the more abundant passenger mutations found in tumors. Recently, the Sleeping Beauty (SB) transposon system has been engineered to model cancer in mice. SB-induced tumors are produced by transposon insertional mutagenesis, thus the tagged mutations facilitate the identification of novel cancer genes. This review provides a brief summary of the SB system and its use in modeling cancer in mice." @default.
• W2048673295 created "2016-06-24" @default.
• W2048673295 creator A5027639088 @default.
• W2048673295 date "2010-08-01" @default.
• W2048673295 modified "2023-09-23" @default.
• W2048673295 title "Transposon-based screens for cancer gene discovery in mouse models" @default.
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• W2048673295 doi "https://doi.org/10.1016/j.semcancer.2010.05.003" @default.
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