FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048680212> ?p ?o ?g. }

• W2048680212 endingPage "2818" @default.
• W2048680212 startingPage "2812" @default.
• W2048680212 abstract "Abstract Macrophages as inflammatory cells are involved in the pathogenesis of atherosclerosis that today is recognized as an inflammatory disease. Activation of coagulation leads to the late complication of atherosclerosis, namely atherothrombosis with its clinical manifestations stroke, unstable angina, myocardial infarction, and sudden cardiac death. Thus inflammation and coagulation play fundamental roles in the pathogenesis of atherosclerosis. We show that the coagulation enzyme thrombin up-regulates oncostatin M (OSM), a pleiotropic cytokine implicated in the pathophysiology of vascular disease, in human monocyte-derived macrophages (MDMs) up to 16.8-fold. A similar effect was seen in human peripheral blood monocytes and human plaque macrophages. In MDMs, the effect of thrombin on OSM was abolished by PPACK and mimicked by a PAR-1–specific peptide. Thrombin induced phosphorylation of ERK1/2 and p38 in MDMs. The ERK1/2 inhibitor PD98059 blocked the effect of thrombin on OSM production in MDMs, whereas the p38 inhibitor SB202190 had no effect. Thrombin induced translocation of c-fos and c-jun to the nucleus of MDMs. Using OSM promoter–luciferase reporter constructs transfected into MDMs, we show that a functional AP-1 site is required for promoter activation by thrombin. We present another link between coagulation and inflammation, which could impact on the pathogenesis of atherosclerosis." @default.
• W2048680212 created "2016-06-24" @default.
• W2048680212 creator A5005182579 @default.
• W2048680212 creator A5008682192 @default.
• W2048680212 creator A5016842679 @default.
• W2048680212 creator A5017014231 @default.
• W2048680212 creator A5020574493 @default.
• W2048680212 creator A5020916056 @default.
• W2048680212 creator A5040310365 @default.
• W2048680212 creator A5042025019 @default.
• W2048680212 creator A5045409568 @default.
• W2048680212 creator A5062343479 @default.
• W2048680212 creator A5066910258 @default.
• W2048680212 creator A5077862111 @default.
• W2048680212 creator A5079387471 @default.
• W2048680212 date "2009-09-24" @default.
• W2048680212 modified "2023-10-15" @default.
• W2048680212 title "Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation" @default.
• W2048680212 cites W1541529837 @default.
• W2048680212 cites W1562744510 @default.
• W2048680212 cites W1963558579 @default.
• W2048680212 cites W1966612449 @default.
• W2048680212 cites W1971169128 @default.
• W2048680212 cites W2007990498 @default.
• W2048680212 cites W2024312453 @default.
• W2048680212 cites W2025192532 @default.
• W2048680212 cites W2036348577 @default.
• W2048680212 cites W2050758464 @default.
• W2048680212 cites W2051603014 @default.
• W2048680212 cites W2051752982 @default.
• W2048680212 cites W2054018735 @default.
• W2048680212 cites W2054247098 @default.
• W2048680212 cites W2058252463 @default.
• W2048680212 cites W2063436562 @default.
• W2048680212 cites W2068520355 @default.
• W2048680212 cites W2071535279 @default.
• W2048680212 cites W2072319964 @default.
• W2048680212 cites W2073751205 @default.
• W2048680212 cites W2077759892 @default.
• W2048680212 cites W2079814968 @default.
• W2048680212 cites W2085215980 @default.
• W2048680212 cites W2088868188 @default.
• W2048680212 cites W2089783160 @default.
• W2048680212 cites W2102673684 @default.
• W2048680212 cites W2103822607 @default.
• W2048680212 cites W2106839512 @default.
• W2048680212 cites W2111721103 @default.
• W2048680212 cites W2112995033 @default.
• W2048680212 cites W2137966179 @default.
• W2048680212 cites W2138182280 @default.
• W2048680212 cites W2141375481 @default.
• W2048680212 cites W2148068999 @default.
• W2048680212 cites W2149206777 @default.
• W2048680212 cites W2152238511 @default.
• W2048680212 cites W2155524664 @default.
• W2048680212 cites W2161961353 @default.
• W2048680212 cites W2164425676 @default.
• W2048680212 cites W2166646911 @default.
• W2048680212 cites W2171111190 @default.
• W2048680212 cites W2324841714 @default.
• W2048680212 doi "https://doi.org/10.1182/blood-2009-01-200915" @default.
• W2048680212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19652200" @default.
• W2048680212 hasPublicationYear "2009" @default.
• W2048680212 type Work @default.
• W2048680212 sameAs 2048680212 @default.
• W2048680212 citedByCount "51" @default.
• W2048680212 countsByYear W20486802122012 @default.
• W2048680212 countsByYear W20486802122013 @default.
• W2048680212 countsByYear W20486802122014 @default.
• W2048680212 countsByYear W20486802122015 @default.
• W2048680212 countsByYear W20486802122016 @default.
• W2048680212 countsByYear W20486802122017 @default.
• W2048680212 countsByYear W20486802122018 @default.
• W2048680212 countsByYear W20486802122019 @default.
• W2048680212 countsByYear W20486802122020 @default.
• W2048680212 countsByYear W20486802122021 @default.
• W2048680212 countsByYear W20486802122022 @default.
• W2048680212 countsByYear W20486802122023 @default.
• W2048680212 crossrefType "journal-article" @default.
• W2048680212 hasAuthorship W2048680212A5005182579 @default.
• W2048680212 hasAuthorship W2048680212A5008682192 @default.
• W2048680212 hasAuthorship W2048680212A5016842679 @default.
• W2048680212 hasAuthorship W2048680212A5017014231 @default.
• W2048680212 hasAuthorship W2048680212A5020574493 @default.
• W2048680212 hasAuthorship W2048680212A5020916056 @default.
• W2048680212 hasAuthorship W2048680212A5040310365 @default.
• W2048680212 hasAuthorship W2048680212A5042025019 @default.
• W2048680212 hasAuthorship W2048680212A5045409568 @default.
• W2048680212 hasAuthorship W2048680212A5062343479 @default.
• W2048680212 hasAuthorship W2048680212A5066910258 @default.
• W2048680212 hasAuthorship W2048680212A5077862111 @default.
• W2048680212 hasAuthorship W2048680212A5079387471 @default.
• W2048680212 hasBestOaLocation W20486802121 @default.
• W2048680212 hasConcept C11988809 @default.
• W2048680212 hasConcept C126322002 @default.
• W2048680212 hasConcept C164027704 @default.
• W2048680212 hasConcept C202751555 @default.
• W2048680212 hasConcept C203014093 @default.

• next