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• W2048685005 abstract "The effects of 8 weeks of dietary exposure to the fungal toxin vomitoxin (25 ppm) on the kinetics of in vitro immunoglobulin (Ig) production and appearance of IgA-secreting cells in lymphocyte culture were assessed in the B6C3F1 mouse. The feeding regimen resulted in an IgA:IgG serum ratio of 2.4 compared to 0.4 in controls indicating that there was dysregulation of IgA production in the systemic compartment. Prior toxin feeding had no effect on viability of Peyer's patch (PP) or splenic lymphocyte cultures. IgA production, as determined by enzyme-linked immunosorbent assay, was significantly greater in treatment PP and splenic lymphocytes cultured for 2-11 days than in corresponding controls. Similar trends were found for IgG production in PP cultures although levels were much lower. There were 1.7 and 2.0 times more IgA-producing cells, as measured by the ELISPOT assay, in freshly prepared PP and splenic lymphocytes from treatment mice compared to control mice, respectively. In contrast, after 2 days there were 10.9, 3.2, and 12.4 times more IgA-secreting cells in concanavalin A (Con A), LPS, and unstimulated treatment PP cultures, respectively, and 4.0, 2.0, and 3.5 times times more IgA-secreting cells in 2-day treatment spleen cultures, respectively. Both IgA and IgG secretion in Con A-stimulated cultures were significantly greater when treatment T cells and control B cells were combined than when control T cells and control B cells were combined. Increased Ig secretion attributable to T cell effects was not observed in LPS-stimulated or unstimulated PP reconstitution cultures or in spleen reconstituted cultures with and without mitogen. The results provide evidence that dietary vomitoxin enhances terminal differentiation of IgA secreting cells in PP. This and resultant migration of IgA secreting cells into the systemic compartment favor a shift from IgG to IgA as the primary serum isotype." @default.
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• W2048685005 date "1991-05-01" @default.
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• W2048685005 title "Dietary exposure to the trichothecene vomitoxin (deoxynivalenol) stimulates terminal differentiation of Peyer's patch B cells to IgA secreting plasma cells" @default.
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• W2048685005 doi "https://doi.org/10.1016/0041-008x(91)90098-y" @default.
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