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- W2048687515 abstract "Here we report a rare case of T-cell prolymphocytic leukemia in whom leukemic killer cells, expressing a cytolytic factor perforin, infiltrated the heart. Perforin may have directly injured myocardial cells which showed marked expression of human leukocyte antigens (HLAs) and intercellular adhesion molecule-1 (ICAM-1) as well as costimulatory molecules B7 and B70, which are ligands for CD28 expressed on T-cells. In spite of chemotherapy against leukemic cells, this autoimmune process finally caused fatal congestive heart failure." @default.
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- W2048687515 title "Perforin-Positive Leukemic Cell Infiltration in the Heart of a Patient with T-Cell Prolymphocytic Leukemia." @default.
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- W2048687515 doi "https://doi.org/10.2169/internalmedicine.34.782" @default.
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