FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048689682> ?p ?o ?g. }

• W2048689682 endingPage "2104" @default.
• W2048689682 startingPage "2096" @default.
• W2048689682 abstract "Deep brain stimulation (DBS) is an established therapy for the treatment of Parkinson's disease (PD) and shows great promise for the treatment of several other disorders. However, while the clinical analysis of DBS has received great attention, a relative paucity of quantitative techniques exists to define the optimal surgical target and most effective stimulation protocol for a given disorder. In this study we describe a methodology that represents an evolutionary addition to the concept of a probabilistic brain atlas, which we call a probabilistic stimulation atlas (PSA). We outline steps to combine quantitative clinical outcome measures with advanced computational models of DBS to identify regions where stimulation-induced activation could provide the best therapeutic improvement on a per-symptom basis. While this methodology is relevant to any form of DBS, we present example results from subthalamic nucleus (STN) DBS for PD. We constructed patient-specific computer models of the volume of tissue activated (VTA) for 163 different stimulation parameter settings which were tested in six patients. We then assigned clinical outcome scores to each VTA and compiled all of the VTAs into a PSA to identify stimulation-induced activation targets that maximized therapeutic response with minimal side effects. The results suggest that selection of both electrode placement and clinical stimulation parameter settings could be tailored to the patient's primary symptoms using patient-specific models and PSAs." @default.
• W2048689682 created "2016-06-24" @default.
• W2048689682 creator A5009856256 @default.
• W2048689682 creator A5034742107 @default.
• W2048689682 creator A5067372681 @default.
• W2048689682 creator A5083835604 @default.
• W2048689682 creator A5087538664 @default.
• W2048689682 date "2011-02-01" @default.
• W2048689682 modified "2023-10-15" @default.
• W2048689682 title "Probabilistic analysis of activation volumes generated during deep brain stimulation" @default.
• W2048689682 cites W133947194 @default.
• W2048689682 cites W161010822 @default.
• W2048689682 cites W1874027545 @default.
• W2048689682 cites W1969696235 @default.
• W2048689682 cites W1996999362 @default.
• W2048689682 cites W2002785976 @default.
• W2048689682 cites W2014786844 @default.
• W2048689682 cites W2017417414 @default.
• W2048689682 cites W2021162984 @default.
• W2048689682 cites W2027407469 @default.
• W2048689682 cites W2029940240 @default.
• W2048689682 cites W2045546537 @default.
• W2048689682 cites W2058764618 @default.
• W2048689682 cites W2061324080 @default.
• W2048689682 cites W2066326028 @default.
• W2048689682 cites W2083932518 @default.
• W2048689682 cites W2106551946 @default.
• W2048689682 cites W2109713218 @default.
• W2048689682 cites W2111624468 @default.
• W2048689682 cites W2112139662 @default.
• W2048689682 cites W2112704483 @default.
• W2048689682 cites W2113543354 @default.
• W2048689682 cites W2115893770 @default.
• W2048689682 cites W2118100625 @default.
• W2048689682 cites W2123208606 @default.
• W2048689682 cites W2123820408 @default.
• W2048689682 cites W2123954634 @default.
• W2048689682 cites W2124594201 @default.
• W2048689682 cites W2125240117 @default.
• W2048689682 cites W2127129065 @default.
• W2048689682 cites W2127424354 @default.
• W2048689682 cites W2132969335 @default.
• W2048689682 cites W2134034633 @default.
• W2048689682 cites W2139526581 @default.
• W2048689682 cites W2140737717 @default.
• W2048689682 cites W2142146640 @default.
• W2048689682 cites W2144639273 @default.
• W2048689682 cites W2146109645 @default.
• W2048689682 cites W2147316895 @default.
• W2048689682 cites W2153774608 @default.
• W2048689682 cites W2154408845 @default.
• W2048689682 cites W2155931363 @default.
• W2048689682 cites W2157502851 @default.
• W2048689682 cites W2158131228 @default.
• W2048689682 cites W2161558564 @default.
• W2048689682 cites W2171899104 @default.
• W2048689682 cites W2183760535 @default.
• W2048689682 cites W2296621543 @default.
• W2048689682 cites W3025643029 @default.
• W2048689682 cites W4376595444 @default.
• W2048689682 doi "https://doi.org/10.1016/j.neuroimage.2010.10.059" @default.
• W2048689682 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3008334" @default.
• W2048689682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20974269" @default.
• W2048689682 hasPublicationYear "2011" @default.
• W2048689682 type Work @default.
• W2048689682 sameAs 2048689682 @default.
• W2048689682 citedByCount "155" @default.
• W2048689682 countsByYear W20486896822012 @default.
• W2048689682 countsByYear W20486896822013 @default.
• W2048689682 countsByYear W20486896822014 @default.
• W2048689682 countsByYear W20486896822015 @default.
• W2048689682 countsByYear W20486896822016 @default.
• W2048689682 countsByYear W20486896822017 @default.
• W2048689682 countsByYear W20486896822018 @default.
• W2048689682 countsByYear W20486896822019 @default.
• W2048689682 countsByYear W20486896822020 @default.
• W2048689682 countsByYear W20486896822021 @default.
• W2048689682 countsByYear W20486896822022 @default.
• W2048689682 countsByYear W20486896822023 @default.
• W2048689682 crossrefType "journal-article" @default.
• W2048689682 hasAuthorship W2048689682A5009856256 @default.
• W2048689682 hasAuthorship W2048689682A5034742107 @default.
• W2048689682 hasAuthorship W2048689682A5067372681 @default.
• W2048689682 hasAuthorship W2048689682A5083835604 @default.
• W2048689682 hasAuthorship W2048689682A5087538664 @default.
• W2048689682 hasBestOaLocation W20486896822 @default.
• W2048689682 hasConcept C126322002 @default.
• W2048689682 hasConcept C154945302 @default.
• W2048689682 hasConcept C15744967 @default.
• W2048689682 hasConcept C169760540 @default.
• W2048689682 hasConcept C24998067 @default.
• W2048689682 hasConcept C2777319143 @default.
• W2048689682 hasConcept C2778542668 @default.
• W2048689682 hasConcept C2779134260 @default.
• W2048689682 hasConcept C2779734285 @default.
• W2048689682 hasConcept C41008148 @default.
• W2048689682 hasConcept C49937458 @default.
• W2048689682 hasConcept C535046627 @default.

• next