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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048693467> ?p ?o ?g. }

• W2048693467 abstract "Mycophenolic acid, an inhibitor of the enzyme IMP dehydrogenase, antagonizes the CTP synthetase inhibitor 3-deazauridine in its anti-proliferative effects on MOLT-3 human T leukemia cells. No depletion of CTP occurred, and decreased amounts of 3-deazuridine-triphosphate were measured in cells incubated with mycophenolic acid and 3-deazuridine. Most probably, these phenomena are related to the increased amounts of PRPP observed, which can result in an increased pyrimidine biosynthesis de novo and, as a consequence, a decreased metabolism of 3-deazauridine via the salvage pathway." @default.
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• W2048693467 date "1995-09-01" @default.
• W2048693467 modified "2023-10-18" @default.
• W2048693467 title "The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: A central role for phosphoribosyl pyrophosphate" @default.
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• W2048693467 doi "https://doi.org/10.1016/0006-2952(95)00228-r" @default.
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