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- W2048695211 abstract "SummaryLabelled thymidine is incorporated into Krebs II ascites cells in vitro for a limited period only. It has been shown that this failure results from a progressive decay in the activity of the enzymes which phosphorylate thymidine. Irradiation with 10 000 r reduces the rate of incorporation of thymidine into the cells and lowers the total amount bound in DNA during the period in which the cells remain metabolically active. The effect of the radiation cannot be attributed to a lack of availability of the precursor within the cells, nor to any damage resulting in loss of activity of the thymidine kinases. It is suggested that radiation slows down the incorporation of TTP into DNA and that the observed kinetics of the phosphorylation reactions can be explained in terms of competitive inhibition of the thymidine kinase by TTP." @default.
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- W2048695211 date "1963-01-01" @default.
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- W2048695211 title "The Incorporation of Thymidine into DNA and Effects of γ-radiation" @default.
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- W2048695211 doi "https://doi.org/10.1080/09553006314551611" @default.
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