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• W2048698013 abstract "Double-stranded (ds) RNA is a biologically active component of many viruses including rhinoviruses infecting the upper respiratory tract. Mucus production is a common symptom of such infections. Here, we show that mucin, the glycoprotein subunit of mucus gels, is transcriptionally upregulated in an NF-kappaB- and p38-dependent manner when homogeneous cultures of epithelial cells are exposed to dsRNA. Furthermore, upstream of p38 in this system, dsRNA stimulates the extracellular release of ATP and activation of cell surface ATP receptors, which are G protein-coupled. This results in the stimulation of phospholipase C and protein kinase C. These findings suggest that ATP receptor antagonists could be used to modulate mucus production induced by virus." @default.
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• W2048698013 date "2003-09-05" @default.
• W2048698013 modified "2023-10-15" @default.
• W2048698013 title "Viral dsRNA activates mucin transcription in airway epithelial cells" @default.
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• W2048698013 doi "https://doi.org/10.1016/s0014-5793(03)00863-9" @default.
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