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- W2048698596 abstract "Systemic administration of kainic acid in C57BL/6 and FVB/N mice induces a comparable level of seizure induction yet results in differential susceptibility to seizure-induced cell death. While kainate administration causes severe hippocampal damage in mice of the FVB/N strain, C57BL/6 mice display no demonstrable cell loss or damage. At present, while the cellular mechanisms underlying strain-dependent differences in susceptibility remain unclear, some of this variation is assumed to have a genetic basis. As glutamate receptors are thought to participate in seizure induction and the subsequent neuronal degeneration that ensues, previous studies have proposed that variation in the precise subunit composition of glutamate receptors may result in differential susceptibility to excitotoxic cell death. Thus, we chose to examine the relationship between the cellular distribution and expression of glutamate receptor subunit proteins and cell loss within the hippocampus in mouse strains resistant and susceptible to kainate-induced excitotoxicity. Using semi-quantitative Western blot techniques and immunohistochemistry with the use of antibodies that recognize subunits of the KA (GluR5,6,7), AMPA (GluR1, GluR2, and GluR4), and NMDA (NMDAR1 and NMDAR2A/2B) receptors, we found no significant strain-dependent differences in the expression or distribution of these glutamate receptor subunits in the intact hippocampus. Following kainate administration, expression changes in ionotropic glutamate receptor subunits paralleled the development of susceptibility to cell death in the FVB/N strain only. Strain differences in hippocampal vulnerability to kainate-induced status epilepticus are not due to glutamate receptor protein expression." @default.
- W2048698596 created "2016-06-24" @default.
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- W2048698596 date "2003-04-01" @default.
- W2048698596 modified "2023-10-10" @default.
- W2048698596 title "Differences in ionotropic glutamate receptor subunit expression are not responsible for strain-dependent susceptibility to excitotoxin-induced injury" @default.
- W2048698596 cites W111663151 @default.
- W2048698596 cites W1548516628 @default.
- W2048698596 cites W1548600249 @default.
- W2048698596 cites W1603732963 @default.
- W2048698596 cites W1843854943 @default.
- W2048698596 cites W19003993 @default.
- W2048698596 cites W1971928338 @default.
- W2048698596 cites W1972183007 @default.
- W2048698596 cites W1976289522 @default.
- W2048698596 cites W1977149656 @default.
- W2048698596 cites W1977966461 @default.
- W2048698596 cites W1978264884 @default.
- W2048698596 cites W1979406476 @default.
- W2048698596 cites W1982853485 @default.
- W2048698596 cites W1990677727 @default.
- W2048698596 cites W1991025191 @default.
- W2048698596 cites W1993975841 @default.
- W2048698596 cites W1995964198 @default.
- W2048698596 cites W1999968276 @default.
- W2048698596 cites W2008029686 @default.
- W2048698596 cites W2009297045 @default.
- W2048698596 cites W2011055552 @default.
- W2048698596 cites W2013474060 @default.
- W2048698596 cites W2015832128 @default.
- W2048698596 cites W2016575029 @default.
- W2048698596 cites W2016619600 @default.
- W2048698596 cites W2016759315 @default.
- W2048698596 cites W2018197873 @default.
- W2048698596 cites W2018339362 @default.
- W2048698596 cites W2020054158 @default.
- W2048698596 cites W2020266231 @default.
- W2048698596 cites W2023413095 @default.
- W2048698596 cites W2023811880 @default.
- W2048698596 cites W2024959564 @default.
- W2048698596 cites W2029960234 @default.
- W2048698596 cites W2035862839 @default.
- W2048698596 cites W2037553441 @default.
- W2048698596 cites W2038884088 @default.
- W2048698596 cites W2039423720 @default.
- W2048698596 cites W2041877030 @default.
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- W2048698596 cites W2048795056 @default.
- W2048698596 cites W2049521887 @default.
- W2048698596 cites W2049523605 @default.
- W2048698596 cites W2049594669 @default.
- W2048698596 cites W2051770770 @default.
- W2048698596 cites W2052264856 @default.
- W2048698596 cites W2056025481 @default.
- W2048698596 cites W2058887458 @default.
- W2048698596 cites W2065169750 @default.
- W2048698596 cites W2071503472 @default.
- W2048698596 cites W2071928136 @default.
- W2048698596 cites W2072729793 @default.
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- W2048698596 cites W2080016031 @default.
- W2048698596 cites W2084369020 @default.
- W2048698596 cites W2090872672 @default.
- W2048698596 cites W2092700031 @default.
- W2048698596 cites W2093919005 @default.
- W2048698596 cites W2103946141 @default.
- W2048698596 cites W2129108032 @default.
- W2048698596 cites W2159030157 @default.
- W2048698596 cites W2160789742 @default.
- W2048698596 cites W2162688668 @default.
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- W2048698596 cites W2168044729 @default.
- W2048698596 cites W2168367599 @default.
- W2048698596 cites W2273738402 @default.
- W2048698596 cites W2316145923 @default.
- W2048698596 cites W240143375 @default.
- W2048698596 cites W2412708681 @default.
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- W2048698596 doi "https://doi.org/10.1016/s0169-328x(03)00048-2" @default.
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