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- W2048718351 abstract "Abstract The collection of whole blood samples on paper, known as dried blood spot (DBS), dates back to the early 1960s in newborn screening for inherited metabolic disorders. DBS offers a number of advantages over conventional blood collection. As a less invasive sampling method, DBS offers simpler sample collection and storage and easier transfer, with reduced infection risk of various pathogens, and requires a smaller blood volume. To date, DBS‐LC‐MS/MS has emerged as an important method for quantitative analysis of small molecules. Despite the increasing popularity of DBS‐LC‐MS/MS, the method has its limitations in assay sensitivity due to the small sample size. Sample quality is often a concern. Systematic assessment on the potential impact of various blood sample properties on accurate quantification of analyte of interest is necessary. Whereas most analytes may be stable on DBS, unstable compounds present another challenge for DBS as enzyme inhibitors cannot be conveniently mixed during sample collection. Improvements on the chemistry of DBS card are desirable. In addition to capturing many representative DBS‐LS‐MS/MS applications, this review highlights some important aspects of developing and validating a rugged DBS‐LC‐MS/MS method for quantitative analysis of small molecules along with DBS sample collection, processing and storage. Copyright © 2009 John Wiley & Sons, Ltd." @default.
- W2048718351 created "2016-06-24" @default.
- W2048718351 creator A5005190976 @default.
- W2048718351 creator A5044413711 @default.
- W2048718351 date "2009-12-16" @default.
- W2048718351 modified "2023-10-18" @default.
- W2048718351 title "Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules" @default.
- W2048718351 cites W1564767317 @default.
- W2048718351 cites W1700762969 @default.
- W2048718351 cites W1875055464 @default.
- W2048718351 cites W1894873888 @default.
- W2048718351 cites W1968189544 @default.
- W2048718351 cites W1970139247 @default.
- W2048718351 cites W1972892197 @default.
- W2048718351 cites W1975124970 @default.
- W2048718351 cites W1977537246 @default.
- W2048718351 cites W1977781602 @default.
- W2048718351 cites W1978365125 @default.
- W2048718351 cites W1979423473 @default.
- W2048718351 cites W1981566444 @default.
- W2048718351 cites W1984703540 @default.
- W2048718351 cites W1990302608 @default.
- W2048718351 cites W1994269537 @default.
- W2048718351 cites W1995305857 @default.
- W2048718351 cites W1996399352 @default.
- W2048718351 cites W2002991206 @default.
- W2048718351 cites W2005872866 @default.
- W2048718351 cites W2007006284 @default.
- W2048718351 cites W2007501521 @default.
- W2048718351 cites W2011509390 @default.
- W2048718351 cites W2012655606 @default.
- W2048718351 cites W2014440976 @default.
- W2048718351 cites W2017051741 @default.
- W2048718351 cites W2019509055 @default.
- W2048718351 cites W2019521917 @default.
- W2048718351 cites W2022946956 @default.
- W2048718351 cites W2024127724 @default.
- W2048718351 cites W2024773741 @default.
- W2048718351 cites W2025349244 @default.
- W2048718351 cites W2027508859 @default.
- W2048718351 cites W2033287768 @default.
- W2048718351 cites W2035416331 @default.
- W2048718351 cites W2038442799 @default.
- W2048718351 cites W2044788142 @default.
- W2048718351 cites W2045278104 @default.
- W2048718351 cites W2047427392 @default.
- W2048718351 cites W2047429706 @default.
- W2048718351 cites W2047706714 @default.
- W2048718351 cites W2050593305 @default.
- W2048718351 cites W2052751346 @default.
- W2048718351 cites W2054718160 @default.
- W2048718351 cites W2058211369 @default.
- W2048718351 cites W2060053138 @default.
- W2048718351 cites W2060116490 @default.
- W2048718351 cites W2060763377 @default.
- W2048718351 cites W2063143853 @default.
- W2048718351 cites W2065576989 @default.
- W2048718351 cites W2066410117 @default.
- W2048718351 cites W2067168371 @default.
- W2048718351 cites W2069756383 @default.
- W2048718351 cites W2072042258 @default.
- W2048718351 cites W2074503383 @default.
- W2048718351 cites W2079710791 @default.
- W2048718351 cites W2081023735 @default.
- W2048718351 cites W2091412617 @default.
- W2048718351 cites W2100063756 @default.
- W2048718351 cites W2102035792 @default.
- W2048718351 cites W2102057504 @default.
- W2048718351 cites W2109417983 @default.
- W2048718351 cites W2110229712 @default.
- W2048718351 cites W2111011526 @default.
- W2048718351 cites W2125388772 @default.
- W2048718351 cites W2129745823 @default.
- W2048718351 cites W2130752680 @default.
- W2048718351 cites W2141333585 @default.
- W2048718351 cites W2142742590 @default.
- W2048718351 cites W2145355107 @default.
- W2048718351 cites W2152766006 @default.
- W2048718351 cites W2153495310 @default.
- W2048718351 cites W2154833816 @default.
- W2048718351 cites W2155793022 @default.
- W2048718351 cites W2156993555 @default.
- W2048718351 cites W2161641226 @default.
- W2048718351 cites W2167779832 @default.
- W2048718351 cites W2168021129 @default.
- W2048718351 cites W2329294493 @default.
- W2048718351 cites W4251237235 @default.
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- W2048718351 doi "https://doi.org/10.1002/bmc.1367" @default.
- W2048718351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20017122" @default.
- W2048718351 hasPublicationYear "2009" @default.
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