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• W2048728045 abstract "Previous studies using Doppler and M-mode echocardiography have demonstrated that abnormalities of left ventricular (LV) diastolic relaxation are sensitive markers of early myocardial dysfunction. Tissue Doppler echocardiography and color M-mode propagation velocity (Vp) are novel noninvasive techniques that provide an estimate of LV relaxation 1–3 and are less dependent on preload. 4,5 Furthermore, mitral infl ow early fi lling (E) can be used in conjunction with tissue Doppler echocardiography early diastolic velocity (EM) and Vp to estimate LV fi lling pressures. 3,4 The present study examines whether subclinical diastolic dysfunction is found in asymptomatic type 1 diabetic patients, and evaluates the relation between diastolic dysfunction and glycemic control using novel echocardiographic techniques.  The study group included 25 type 1 diabetic patients who were compared with 26 age- and gendermatched normal volunteers. Exclusion criteria were any history of hypertension, myocardial infarction, unstable angina pectoris, or congestive heart failure. Subjects were also excluded if they had any evidence of global or regional LV dysfunction, valvular stenosis, or regurgitation, or abnormal end-diastolic or endsystolic dimensions on transthoracic echocardiography. All participants had normal electrocardiograms. The study protocol was approved by an institutional review board, and all participants provided informed consent. Participants were examined in the supine position by 2-dimensional– guided transthoracic standard pulsed, color Doppler, and tissue Doppler echocardiography using an Acuson Sequoia (Mountain View, California) echocardiographic machine equipped with tissue Doppler echocardiographic technology. Recordings were acquired with a 1.7 to 3.5 harmonic Doppler transducer. Recordings of myocardial wall velocities, transmitral Doppler fl ow, and 2-dimensional images were obtained from the apical acoustic window. M-mode and 2-dimensional echocardiographic images of the left ventricle were obtained for evaluation of ventricular septal and posterior wall" @default.
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• W2048728045 date "2003-06-01" @default.
• W2048728045 modified "2023-10-13" @default.
• W2048728045 title "Relation of hemoglobin A1c to left ventricular relaxation in patients with type 1 diabetes mellitus and without overt heart disease" @default.
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• W2048728045 doi "https://doi.org/10.1016/s0002-9149(03)00414-4" @default.
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