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- W2048734194 abstract "Beta-adrenergic receptor blockade has been demonstrated to reduce obstruction of the left ventricular outflow tract in patients with idiopathic hypertrophic subaortic stenosis (IHSS) and has also proved helpful in reducing angina pectoris due to ischemic heart disease. Accordingly, the effects of oral propranolol on the clinical state and the level and duration of exercise required to produce angina pectoris in 8 patients with IHSS were studied. Five patients exhibited considerable benefit from propranolol initially but two of them deteriorated and ultimately required operation, which the other 3 are being maintained on the beta-adrenergic blocking drug and continue to exhibit improvement. Three patients showed no significant improvement with propranolol and 2 of them have been operated upon with some amelioration of symptoms. The mechanism by which propranolol is efficacious in IHSS is probably related to a diminution of myocardial O2 requirements resulting from the reduction of wall tension, velocity of contraction and heart rate induced by this drug. The natural history of IHSS is reviewed, as are the results of propranolol treatment reported by other investigators. On the basis of all of the available data, it is suggested that a trial of propranolol therapy be attempted prior to deciding upon operative treatment in patients with IHSS whose chief symptom is disabling angina pectoris." @default.
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- W2048734194 date "1968-11-01" @default.
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- W2048734194 title "Chronic beta adrenergic receptor blockade in the treatment of idiopathic hypertrophic subaortic stenosis" @default.
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- W2048734194 doi "https://doi.org/10.1016/0033-0620(68)90011-x" @default.
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