FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048736616> ?p ?o ?g. }

• W2048736616 endingPage "902" @default.
• W2048736616 startingPage "890" @default.
• W2048736616 abstract "Endothelial progenitor cells (EPCs) play a significant role in multiple biological processes such as vascular homeostasis, regeneration, and tumor angiogenesis. This makes them a promising cell of choice for studying a variety of biological processes, toxicity assays, biomaterial–cell interaction studies, as well as in tissue-engineering applications. In this study, we report the generation of two clones of SV40-immortalized EPCs from umbilical cord blood. These cells retained most of the functional features of mature endothelial cells and showed no indication of senescence after repeated culture for more than 240 days. Extensive functional characterization of the immortalized cells by western blot, flow cytometry, and immunofluorescence studies substantiated that these cells retained their ability to synthesize nitric oxide, von Willebrand factor, P-Selectin etc. These cells achieved unlimited proliferation potential subsequent to inactivation of the cyclin-dependent kinase inhibitor p21, but failed to form colonies on soft agar. We also show their enhanced growth and survival on vascular biomaterials compared to parental cultures in late population doubling. These immortalized EPCs can be used as a cellular model system for studying the biology of these cells, gene manipulation experiments, cell–biomaterial interactions, as well as a variety of tissue-engineering applications." @default.
• W2048736616 created "2016-06-24" @default.
• W2048736616 creator A5003656855 @default.
• W2048736616 creator A5014409172 @default.
• W2048736616 creator A5021010603 @default.
• W2048736616 creator A5027696159 @default.
• W2048736616 creator A5031178816 @default.
• W2048736616 creator A5049976471 @default.
• W2048736616 creator A5051464513 @default.
• W2048736616 creator A5054114054 @default.
• W2048736616 creator A5055376109 @default.
• W2048736616 creator A5065442564 @default.
• W2048736616 creator A5077338813 @default.
• W2048736616 date "2012-11-01" @default.
• W2048736616 modified "2023-10-03" @default.
• W2048736616 title "Immortalized Functional Endothelial Progenitor Cell Lines from Umbilical Cord Blood for Vascular Tissue Engineering" @default.
• W2048736616 cites W1484777774 @default.
• W2048736616 cites W151602848 @default.
• W2048736616 cites W1545398558 @default.
• W2048736616 cites W1799167605 @default.
• W2048736616 cites W1810419160 @default.
• W2048736616 cites W1963655153 @default.
• W2048736616 cites W1975292043 @default.
• W2048736616 cites W1979485167 @default.
• W2048736616 cites W2004239282 @default.
• W2048736616 cites W2008018400 @default.
• W2048736616 cites W2015089387 @default.
• W2048736616 cites W2015987532 @default.
• W2048736616 cites W2016393918 @default.
• W2048736616 cites W2016757722 @default.
• W2048736616 cites W2018686909 @default.
• W2048736616 cites W2020476872 @default.
• W2048736616 cites W2021806535 @default.
• W2048736616 cites W2027009674 @default.
• W2048736616 cites W2027345413 @default.
• W2048736616 cites W2029437863 @default.
• W2048736616 cites W2031462636 @default.
• W2048736616 cites W2035940544 @default.
• W2048736616 cites W2042039121 @default.
• W2048736616 cites W2049466721 @default.
• W2048736616 cites W2053704719 @default.
• W2048736616 cites W2059147822 @default.
• W2048736616 cites W2062085206 @default.
• W2048736616 cites W2065719713 @default.
• W2048736616 cites W2073136932 @default.
• W2048736616 cites W2089031738 @default.
• W2048736616 cites W2091809756 @default.
• W2048736616 cites W2098282622 @default.
• W2048736616 cites W2099837423 @default.
• W2048736616 cites W2108482850 @default.
• W2048736616 cites W2110419512 @default.
• W2048736616 cites W2111942707 @default.
• W2048736616 cites W2115317412 @default.
• W2048736616 cites W2115564331 @default.
• W2048736616 cites W2128485404 @default.
• W2048736616 cites W2129727010 @default.
• W2048736616 cites W2135920231 @default.
• W2048736616 cites W2145639716 @default.
• W2048736616 cites W2157508179 @default.
• W2048736616 cites W2332168754 @default.
• W2048736616 cites W2332596112 @default.
• W2048736616 cites W2413545010 @default.
• W2048736616 cites W5175567 @default.
• W2048736616 doi "https://doi.org/10.1089/ten.tec.2011.0482" @default.
• W2048736616 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3483052" @default.
• W2048736616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22889128" @default.
• W2048736616 hasPublicationYear "2012" @default.
• W2048736616 type Work @default.
• W2048736616 sameAs 2048736616 @default.
• W2048736616 citedByCount "6" @default.
• W2048736616 countsByYear W20487366162018 @default.
• W2048736616 countsByYear W20487366162019 @default.
• W2048736616 countsByYear W20487366162020 @default.
• W2048736616 countsByYear W20487366162022 @default.
• W2048736616 crossrefType "journal-article" @default.
• W2048736616 hasAuthorship W2048736616A5003656855 @default.
• W2048736616 hasAuthorship W2048736616A5014409172 @default.
• W2048736616 hasAuthorship W2048736616A5021010603 @default.
• W2048736616 hasAuthorship W2048736616A5027696159 @default.
• W2048736616 hasAuthorship W2048736616A5031178816 @default.
• W2048736616 hasAuthorship W2048736616A5049976471 @default.
• W2048736616 hasAuthorship W2048736616A5051464513 @default.
• W2048736616 hasAuthorship W2048736616A5054114054 @default.
• W2048736616 hasAuthorship W2048736616A5055376109 @default.
• W2048736616 hasAuthorship W2048736616A5065442564 @default.
• W2048736616 hasAuthorship W2048736616A5077338813 @default.
• W2048736616 hasBestOaLocation W20487366162 @default.
• W2048736616 hasConcept C123012128 @default.
• W2048736616 hasConcept C201750760 @default.
• W2048736616 hasConcept C202751555 @default.
• W2048736616 hasConcept C203014093 @default.
• W2048736616 hasConcept C2780152582 @default.
• W2048736616 hasConcept C2780394083 @default.
• W2048736616 hasConcept C28328180 @default.
• W2048736616 hasConcept C49892992 @default.
• W2048736616 hasConcept C502942594 @default.
• W2048736616 hasConcept C54355233 @default.
• W2048736616 hasConcept C55493867 @default.

• next