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• W2048743877 abstract "It has been known that pinealocytes contain the highest level of D-aspartate among various neuroendocrine cells in the rat. Here, we report that exogenous D-aspartate strongly inhibited norepinephrine-dependent melatonin synthesis in the rat pineal gland, the concentration required for 50% inhibition being 75 microM. This inhibition was due at least partly to decreased norepinephrine-dependent serotonin N-acetyltransferase activity. Upon incubation, D-aspartate was gradually released from pinealocytes and accumulated in the incubation medium as determined by high-performance liquid chromatography on a Pirkle-type chiral column. These results suggest that D-aspartate acts as a negative regulator for melatonin synthesis in the pineal gland." @default.
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• W2048743877 date "1998-06-01" @default.
• W2048743877 modified "2023-10-10" @default.
• W2048743877 title "d-Aspartate modulates melatonin synthesis in rat pinealocytes" @default.
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• W2048743877 doi "https://doi.org/10.1016/s0304-3940(98)00414-5" @default.
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