FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048753038> ?p ?o ?g. }

• W2048753038 abstract "The calcium probe, Fura 2, is used to establish and partially characterize histamine-, carbachol-, and forskolin-induced calcium transients in enriched parietal cell populations prepared by centrifugal elutriation of dispersed rat fundic mucosa cell isolates. The magnitude of the maximal carbachol response, which is blocked by atropine but not cimetidine, is nearly five times that of histamine or forskolin. Time to peak responses for carbachol, forskolin, and histamine are approximately 7, 17, and 28 sec, respectively. Carbachol-, histamine-, and forskolin-induced increases in Fura 2 fluorescence appear dependent upon extracellular calcium, since these responses are attenuated in low calcium media and blocked by EGTA in low-calcium media or by lanthanum in high- or low-calcium medium. Trifluoperazine and fenoctimine, at concentrations that inhibit secretion, have no effect on either carbachol- or histamine-induced increases in cytosolic calcium. Seven major calcium/EGTA-sensitive phosphoproteins are identified by SDS-PAGE electrophoresis of ATP 32P-labeled cell sonicates. We conclude that cytosolic calcium in enriched rat gastric parietal cell populations is regulated by secretagogue receptor-controlled calcium channels. We postulate that these channels may be controlled by cyclic AMP-dependent phosphorylation, since neither changes in cyclic AMP nor calcium alone mediate the effects of secretagogues entirely, but the interplay between these two second-messenger systems potentiates the actions of these agents. The role of cytosolic calcium as a second messenger in secretagogue action appears similar to that of cyclic AMP in that a specific cellular concentration must be reached to initiate acid secretion." @default.
• W2048753038 created "2016-06-24" @default.
• W2048753038 creator A5015687559 @default.
• W2048753038 creator A5026276738 @default.
• W2048753038 creator A5036973484 @default.
• W2048753038 creator A5078246492 @default.
• W2048753038 creator A5083930738 @default.
• W2048753038 date "1989-06-01" @default.
• W2048753038 modified "2023-09-26" @default.
• W2048753038 title "Fura 2 analysis of cytosolic calcium regulation in elutriated rat gastric parietal cells" @default.
• W2048753038 cites W1487598557 @default.
• W2048753038 cites W1604047450 @default.
• W2048753038 cites W2002658312 @default.
• W2048753038 cites W2009218821 @default.
• W2048753038 cites W2010946083 @default.
• W2048753038 cites W2019458766 @default.
• W2048753038 cites W2023350216 @default.
• W2048753038 cites W2024625640 @default.
• W2048753038 cites W2024817433 @default.
• W2048753038 cites W2033208846 @default.
• W2048753038 cites W2034110776 @default.
• W2048753038 cites W2059245598 @default.
• W2048753038 cites W2073023290 @default.
• W2048753038 cites W2089675131 @default.
• W2048753038 cites W2122828308 @default.
• W2048753038 cites W2141260882 @default.
• W2048753038 cites W2146927479 @default.
• W2048753038 cites W2223083162 @default.
• W2048753038 cites W2323733023 @default.
• W2048753038 cites W2396170225 @default.
• W2048753038 cites W244093609 @default.
• W2048753038 cites W2460203176 @default.
• W2048753038 cites W82133889 @default.
• W2048753038 doi "https://doi.org/10.1002/jcp.1041390325" @default.
• W2048753038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2472414" @default.
• W2048753038 hasPublicationYear "1989" @default.
• W2048753038 type Work @default.
• W2048753038 sameAs 2048753038 @default.
• W2048753038 citedByCount "13" @default.
• W2048753038 crossrefType "journal-article" @default.
• W2048753038 hasAuthorship W2048753038A5015687559 @default.
• W2048753038 hasAuthorship W2048753038A5026276738 @default.
• W2048753038 hasAuthorship W2048753038A5036973484 @default.
• W2048753038 hasAuthorship W2048753038A5078246492 @default.
• W2048753038 hasAuthorship W2048753038A5083930738 @default.
• W2048753038 hasConcept C1122143 @default.
• W2048753038 hasConcept C126322002 @default.
• W2048753038 hasConcept C134018914 @default.
• W2048753038 hasConcept C163235415 @default.
• W2048753038 hasConcept C170493617 @default.
• W2048753038 hasConcept C181199279 @default.
• W2048753038 hasConcept C185592680 @default.
• W2048753038 hasConcept C24998067 @default.
• W2048753038 hasConcept C2777504413 @default.
• W2048753038 hasConcept C2777658833 @default.
• W2048753038 hasConcept C2778470358 @default.
• W2048753038 hasConcept C2778988552 @default.
• W2048753038 hasConcept C2779276759 @default.
• W2048753038 hasConcept C2779743957 @default.
• W2048753038 hasConcept C2780161494 @default.
• W2048753038 hasConcept C49039625 @default.
• W2048753038 hasConcept C519063684 @default.
• W2048753038 hasConcept C55493867 @default.
• W2048753038 hasConcept C71924100 @default.
• W2048753038 hasConcept C86803240 @default.
• W2048753038 hasConcept C98539663 @default.
• W2048753038 hasConceptScore W2048753038C1122143 @default.
• W2048753038 hasConceptScore W2048753038C126322002 @default.
• W2048753038 hasConceptScore W2048753038C134018914 @default.
• W2048753038 hasConceptScore W2048753038C163235415 @default.
• W2048753038 hasConceptScore W2048753038C170493617 @default.
• W2048753038 hasConceptScore W2048753038C181199279 @default.
• W2048753038 hasConceptScore W2048753038C185592680 @default.
• W2048753038 hasConceptScore W2048753038C24998067 @default.
• W2048753038 hasConceptScore W2048753038C2777504413 @default.
• W2048753038 hasConceptScore W2048753038C2777658833 @default.
• W2048753038 hasConceptScore W2048753038C2778470358 @default.
• W2048753038 hasConceptScore W2048753038C2778988552 @default.
• W2048753038 hasConceptScore W2048753038C2779276759 @default.
• W2048753038 hasConceptScore W2048753038C2779743957 @default.
• W2048753038 hasConceptScore W2048753038C2780161494 @default.
• W2048753038 hasConceptScore W2048753038C49039625 @default.
• W2048753038 hasConceptScore W2048753038C519063684 @default.
• W2048753038 hasConceptScore W2048753038C55493867 @default.
• W2048753038 hasConceptScore W2048753038C71924100 @default.
• W2048753038 hasConceptScore W2048753038C86803240 @default.
• W2048753038 hasConceptScore W2048753038C98539663 @default.
• W2048753038 hasLocation W20487530381 @default.
• W2048753038 hasLocation W20487530382 @default.
• W2048753038 hasOpenAccess W2048753038 @default.
• W2048753038 hasPrimaryLocation W20487530381 @default.
• W2048753038 hasRelatedWork W1969102182 @default.
• W2048753038 hasRelatedWork W1974658456 @default.
• W2048753038 hasRelatedWork W1996794818 @default.
• W2048753038 hasRelatedWork W2017484433 @default.
• W2048753038 hasRelatedWork W2048753038 @default.
• W2048753038 hasRelatedWork W2071964886 @default.
• W2048753038 hasRelatedWork W2073023290 @default.
• W2048753038 hasRelatedWork W2139998848 @default.
• W2048753038 hasRelatedWork W2407105960 @default.

• next