FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048762945> ?p ?o ?g. }

• W2048762945 endingPage "124" @default.
• W2048762945 startingPage "117" @default.
• W2048762945 abstract "During the acute-phase reaction, SAA (serum amyloid A) replaces apoA-I (apolipoprotein A-I) as the major HDL (high-density lipoprotein)-associated apolipoprotein. A remarkable portion of SAA exists in a lipid-free/lipid-poor form and promotes ABCA1 (ATP-binding cassette transporter A1)-dependent cellular cholesterol efflux. In contrast with lipid-free apoA-I and apoE, lipid-free SAA was recently reported to mobilize SR-BI (scavenger receptor class B, type I)-dependent cellular cholesterol efflux [Van der Westhuyzen, Cai, de Beer and de Beer (2005) J. Biol. Chem. 280, 35890–35895]. This unique property could strongly affect cellular cholesterol mobilization during inflammation. However, in the present study, we show that overexpression of SR-BI in HEK-293 cells (human embryonic kidney cells) (devoid of ABCA1) failed to mobilize cholesterol to lipid-free or lipid-poor SAA. Only reconstituted vesicles containing phospholipids and SAA promoted SR-BI-mediated cholesterol efflux. Cholesterol efflux from HEK-293 and HEK-293[SR-BI] cells to lipid-free and lipid-poor SAA was minimal, while efficient efflux was observed from fibroblasts and CHO cells (Chinese-hamster ovary cells) both expressing functional ABCA1. Overexpression of SR-BI in CHO cells strongly attenuated cholesterol efflux to lipid-free SAA even in the presence of an SR-BI-blocking IgG. This implies that SR-BI attenuates ABCA1-mediated cholesterol efflux in a way that is not dependent on SR-BI-mediated re-uptake of cholesterol. The present in vitro experiments demonstrate that the lipidation status of SAA is a critical factor governing cholesterol acceptor properties of this amphipathic apolipoprotein. In addition, we demonstrate that SAA mediates cellular cholesterol efflux via the ABCA1 and/or SR-BI pathway in a similar way to apoA-I." @default.
• W2048762945 created "2016-06-24" @default.
• W2048762945 creator A5018637989 @default.
• W2048762945 creator A5040465206 @default.
• W2048762945 creator A5058791594 @default.
• W2048762945 creator A5065712472 @default.
• W2048762945 creator A5078911757 @default.
• W2048762945 creator A5081012741 @default.
• W2048762945 date "2007-01-25" @default.
• W2048762945 modified "2023-09-27" @default.
• W2048762945 title "The lipidation status of acute-phase protein serum amyloid A determines cholesterol mobilization via scavenger receptor class B, type I" @default.
• W2048762945 cites W1557827218 @default.
• W2048762945 cites W1574745553 @default.
• W2048762945 cites W1964894424 @default.
• W2048762945 cites W1966609176 @default.
• W2048762945 cites W1967468249 @default.
• W2048762945 cites W1971594434 @default.
• W2048762945 cites W1978075735 @default.
• W2048762945 cites W1982516699 @default.
• W2048762945 cites W1984658452 @default.
• W2048762945 cites W1985170971 @default.
• W2048762945 cites W2000011436 @default.
• W2048762945 cites W2002389701 @default.
• W2048762945 cites W2020779473 @default.
• W2048762945 cites W2023864554 @default.
• W2048762945 cites W2029846939 @default.
• W2048762945 cites W2034552386 @default.
• W2048762945 cites W2036665803 @default.
• W2048762945 cites W2053100793 @default.
• W2048762945 cites W2059256286 @default.
• W2048762945 cites W2062030534 @default.
• W2048762945 cites W2069896294 @default.
• W2048762945 cites W2070047410 @default.
• W2048762945 cites W2071043133 @default.
• W2048762945 cites W2072113749 @default.
• W2048762945 cites W2072364830 @default.
• W2048762945 cites W2074239164 @default.
• W2048762945 cites W2075877358 @default.
• W2048762945 cites W2075953638 @default.
• W2048762945 cites W2079469669 @default.
• W2048762945 cites W2092270878 @default.
• W2048762945 cites W2095153977 @default.
• W2048762945 cites W2103602099 @default.
• W2048762945 cites W2114311313 @default.
• W2048762945 cites W2114655341 @default.
• W2048762945 cites W2115220026 @default.
• W2048762945 cites W2117622708 @default.
• W2048762945 cites W2122402164 @default.
• W2048762945 cites W2123960592 @default.
• W2048762945 cites W2126736180 @default.
• W2048762945 cites W2131211557 @default.
• W2048762945 cites W2140049957 @default.
• W2048762945 cites W2144275895 @default.
• W2048762945 cites W2145875299 @default.
• W2048762945 cites W2147558974 @default.
• W2048762945 cites W2149959604 @default.
• W2048762945 cites W2150691772 @default.
• W2048762945 cites W2151817114 @default.
• W2048762945 cites W2153348212 @default.
• W2048762945 cites W2153416061 @default.
• W2048762945 cites W2156107349 @default.
• W2048762945 cites W2156818917 @default.
• W2048762945 cites W2160591905 @default.
• W2048762945 cites W2322722937 @default.
• W2048762945 cites W43375554 @default.
• W2048762945 doi "https://doi.org/10.1042/bj20061406" @default.
• W2048762945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1783981" @default.
• W2048762945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17034364" @default.
• W2048762945 hasPublicationYear "2007" @default.
• W2048762945 type Work @default.
• W2048762945 sameAs 2048762945 @default.
• W2048762945 citedByCount "45" @default.
• W2048762945 countsByYear W20487629452012 @default.
• W2048762945 countsByYear W20487629452013 @default.
• W2048762945 countsByYear W20487629452014 @default.
• W2048762945 countsByYear W20487629452015 @default.
• W2048762945 countsByYear W20487629452016 @default.
• W2048762945 countsByYear W20487629452017 @default.
• W2048762945 countsByYear W20487629452018 @default.
• W2048762945 countsByYear W20487629452020 @default.
• W2048762945 countsByYear W20487629452021 @default.
• W2048762945 countsByYear W20487629452022 @default.
• W2048762945 countsByYear W20487629452023 @default.
• W2048762945 crossrefType "journal-article" @default.
• W2048762945 hasAuthorship W2048762945A5018637989 @default.
• W2048762945 hasAuthorship W2048762945A5040465206 @default.
• W2048762945 hasAuthorship W2048762945A5058791594 @default.
• W2048762945 hasAuthorship W2048762945A5065712472 @default.
• W2048762945 hasAuthorship W2048762945A5078911757 @default.
• W2048762945 hasAuthorship W2048762945A5081012741 @default.
• W2048762945 hasBestOaLocation W20487629452 @default.
• W2048762945 hasConcept C104317684 @default.
• W2048762945 hasConcept C110459506 @default.
• W2048762945 hasConcept C149011108 @default.
• W2048762945 hasConcept C170493617 @default.
• W2048762945 hasConcept C175656101 @default.
• W2048762945 hasConcept C185592680 @default.
• W2048762945 hasConcept C190283241 @default.

• next