FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048768836> ?p ?o ?g. }

• W2048768836 endingPage "A0017" @default.
• W2048768836 startingPage "A0017" @default.
• W2048768836 abstract "Aspirin (acetylsalicylic acid, ASA) is the most popular non-steroidal anti-inflammatory drug. However, due to its action on cyclooxygenase and its acid nature, aspirin is associated with adverse gastrointestinal effects. In an effort to minimize these side effects, NO-donor and H2S-donor ASA co-drugs have been designed and tested. Their mass spectrometric behavior is now analyzed and reported. Positive ions were obtained by electrospray ionization involving protonation or alkali metal attachment. Their dissociation processes have been studied by collision induced dissociation in a triple quadrupole instrument. High mass accuracy measurements have been recorded on a Fourier transform ion cyclotron resonance mass spectrometer. The protonated molecules dissociate by an exclusive or largely prevailing path leading to acetyloxy-substituted benzoyl cation, namely an ASA unit. The process is reminiscent of the enzymatic hydrolysis, releasing intact ASA to a large extent. Only at higher collision energy does the formal ketene loss disrupt the ASA moiety. The gas phase chemistry of protonated ASA-releasing drugs develops along elementary dissociation steps analogous to the reactive processes in complex biological environments. This notion may provide a tool for preliminary testing of new compounds." @default.
• W2048768836 created "2016-06-24" @default.
• W2048768836 creator A5014553586 @default.
• W2048768836 creator A5023324483 @default.
• W2048768836 creator A5026853507 @default.
• W2048768836 creator A5046972661 @default.
• W2048768836 creator A5085797426 @default.
• W2048768836 date "2013-01-01" @default.
• W2048768836 modified "2023-10-16" @default.
• W2048768836 title "Tandem Mass Spectrometry of Nitric Oxide and Hydrogen Sulfide Releasing Aspirins: A Hint into Activity Behavior" @default.
• W2048768836 cites W1488365705 @default.
• W2048768836 cites W1971154550 @default.
• W2048768836 cites W1977988210 @default.
• W2048768836 cites W1997797279 @default.
• W2048768836 cites W2021120412 @default.
• W2048768836 cites W2023215552 @default.
• W2048768836 cites W2028190096 @default.
• W2048768836 cites W2043896152 @default.
• W2048768836 cites W2047465266 @default.
• W2048768836 cites W2048036642 @default.
• W2048768836 cites W2055109009 @default.
• W2048768836 cites W2069626089 @default.
• W2048768836 cites W2088634149 @default.
• W2048768836 cites W2092653007 @default.
• W2048768836 cites W2137282928 @default.
• W2048768836 cites W2149381773 @default.
• W2048768836 cites W2152920125 @default.
• W2048768836 cites W2328350853 @default.
• W2048768836 cites W2783594138 @default.
• W2048768836 doi "https://doi.org/10.5702/massspectrometry.a0017" @default.
• W2048768836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3967006" @default.
• W2048768836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24860707" @default.
• W2048768836 hasPublicationYear "2013" @default.
• W2048768836 type Work @default.
• W2048768836 sameAs 2048768836 @default.
• W2048768836 citedByCount "2" @default.
• W2048768836 countsByYear W20487688362016 @default.
• W2048768836 countsByYear W20487688362022 @default.
• W2048768836 crossrefType "journal-article" @default.
• W2048768836 hasAuthorship W2048768836A5014553586 @default.
• W2048768836 hasAuthorship W2048768836A5023324483 @default.
• W2048768836 hasAuthorship W2048768836A5026853507 @default.
• W2048768836 hasAuthorship W2048768836A5046972661 @default.
• W2048768836 hasAuthorship W2048768836A5085797426 @default.
• W2048768836 hasBestOaLocation W20487688361 @default.
• W2048768836 hasConcept C102931765 @default.
• W2048768836 hasConcept C106289968 @default.
• W2048768836 hasConcept C145148216 @default.
• W2048768836 hasConcept C162356407 @default.
• W2048768836 hasConcept C170552419 @default.
• W2048768836 hasConcept C176107965 @default.
• W2048768836 hasConcept C178790620 @default.
• W2048768836 hasConcept C185592680 @default.
• W2048768836 hasConcept C193055867 @default.
• W2048768836 hasConcept C30095370 @default.
• W2048768836 hasConcept C31827203 @default.
• W2048768836 hasConcept C3896420 @default.
• W2048768836 hasConcept C39527238 @default.
• W2048768836 hasConcept C40684141 @default.
• W2048768836 hasConcept C43617362 @default.
• W2048768836 hasConceptScore W2048768836C102931765 @default.
• W2048768836 hasConceptScore W2048768836C106289968 @default.
• W2048768836 hasConceptScore W2048768836C145148216 @default.
• W2048768836 hasConceptScore W2048768836C162356407 @default.
• W2048768836 hasConceptScore W2048768836C170552419 @default.
• W2048768836 hasConceptScore W2048768836C176107965 @default.
• W2048768836 hasConceptScore W2048768836C178790620 @default.
• W2048768836 hasConceptScore W2048768836C185592680 @default.
• W2048768836 hasConceptScore W2048768836C193055867 @default.
• W2048768836 hasConceptScore W2048768836C30095370 @default.
• W2048768836 hasConceptScore W2048768836C31827203 @default.
• W2048768836 hasConceptScore W2048768836C3896420 @default.
• W2048768836 hasConceptScore W2048768836C39527238 @default.
• W2048768836 hasConceptScore W2048768836C40684141 @default.
• W2048768836 hasConceptScore W2048768836C43617362 @default.
• W2048768836 hasIssue "1" @default.
• W2048768836 hasLocation W20487688361 @default.
• W2048768836 hasLocation W20487688362 @default.
• W2048768836 hasLocation W20487688363 @default.
• W2048768836 hasLocation W20487688364 @default.
• W2048768836 hasLocation W20487688365 @default.
• W2048768836 hasLocation W20487688366 @default.
• W2048768836 hasLocation W20487688367 @default.
• W2048768836 hasOpenAccess W2048768836 @default.
• W2048768836 hasPrimaryLocation W20487688361 @default.
• W2048768836 hasRelatedWork W1848139213 @default.
• W2048768836 hasRelatedWork W1972560077 @default.
• W2048768836 hasRelatedWork W1979519975 @default.
• W2048768836 hasRelatedWork W1981767081 @default.
• W2048768836 hasRelatedWork W1982928186 @default.
• W2048768836 hasRelatedWork W1998082377 @default.
• W2048768836 hasRelatedWork W2003329936 @default.
• W2048768836 hasRelatedWork W2006567794 @default.
• W2048768836 hasRelatedWork W2012800452 @default.
• W2048768836 hasRelatedWork W2013811270 @default.
• W2048768836 hasRelatedWork W2017505837 @default.
• W2048768836 hasRelatedWork W2021400214 @default.
• W2048768836 hasRelatedWork W2049341481 @default.

• next