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- W2048769734 abstract "1-(3-Hydroxy-4-methoxybenzyl)-2-alkyl-6,7-methylenedioxytetrahydroisoquinolines (3a–c), derived from the D1, selective antagonist S-bulbocapnine by cleavage of the bond between the 2 aromatic moieties, have been synthesized and their in vitro affinity towards D1 and D2 receptors evaluated. Of the compounds tested, the 2-methyl derivative 3a while showing poor affinity towards D1 receptors was able to inhibit the D2 radioligand 3H-raclopride binding by 60% at 10−5 M. Conformational analysis allows reasonable explanations of the loss of D2-affinity of 3a with respect to the model." @default.
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- W2048769734 date "1994-01-01" @default.
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- W2048769734 title "Synthesis of some 1-(3-hydroxy-4-methoxybenzyl)-2-alkyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinolines and their binding affinities to DA receptor subtypes" @default.
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- W2048769734 doi "https://doi.org/10.1016/0223-5234(94)90126-0" @default.
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