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• W2048771303 abstract "Keywords Personalised diet Doability Categorisation Ethical and social issuesIntroductionPersonalised diets (PD) are ‘the present’, ‘the future’, ‘ofno interest’ or ‘impossible’, depending on whom one asks.However, in my research I will show that we should notargue about the PD in a digital way, yes or no, and that it ismore fruitful to investigate where and how the PD is‘doable’. Moreover, I will argue that although constructingdoable problems is a very practical process, it ought not tobe ignored that this very process might have unintendedsocial and ethical consequences.DoabilityThe science researcher Fujimura has introduced the term‘doability’ to stress that scientists do not just study theoret-ical problems. On the contrary, from the perspective thatscientific work is essentially practical work she argues thatscientists, to analyse a problem, have to make that scientificwork doable in a concrete scientific practice. That means,that work tasks have to be made doable on various levels oftheworkorganisation:theexperiment,thelaboratoryandtherelevant social worlds [1, 2]. So, to construct doable prob-lems, the necessary equipment, tools, skills and the like needto be available to make an experiment work. Furthermore,the laboratoryneeds tobe organised,equippedand modelledaccordingly. Finally support must be recruited in terms offunding and foreseen relevance in application.Achieving doability on all three levels requires a lot ofwork: various elements in the research situation have to bemanipulated and several strategic organisational decisionshave to be made in order to construct a doable problem [1,2]. So, at some locations a problem is doable, whereas atothers it is not.The (un)doable personalised dietAt some work places the PD is not doable at all. Scientistsexclusively working with animal models or geneticallyidentical cell lines, for instance, have no access to inter-individual variation. In this world, the PD is undoable. Themain ingredient in this world is missing: the individual. Ina second, smaller group of work places, due to theirinstitutional nature and organisation researchers havepatient (or healthy volunteer) access. When the analysis isnot directed towards this variation, it will be activelyexcluded (e.g. as biological noise). Where it is consideredrelevant, researchers have made the PD doable by rede-fining it: instead of the really individualised diet, theyconstructed the PD as based upon a limited number ofmarkers. This way, the bulk of human variation is excludedand the remaining variation is used to assign a diet tospecific risk groups. Instead of individualised diets one candistinguish between certain type-diets. So, nutrigenomicsscientists in these laboratories actively modify the meaningof personalised to make the (not-sopersonalised) PDdoable. In the process of doing so they classify individualsinto categories: Twenty-two SNP’s including four non-synonymous were detected in SLC23A1. Nearly all of the" @default.
• W2048771303 created "2016-06-24" @default.
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• W2048771303 date "2007-09-19" @default.
• W2048771303 modified "2023-10-16" @default.
• W2048771303 title "Personalised diet: is it doable? Individuality at different sites of nutrigenomic practice" @default.
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• W2048771303 doi "https://doi.org/10.1007/s12263-007-0021-x" @default.
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