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- W2048772020 abstract "Background In the SIV/macaque model of HIV in man, live attenuated virus confers the most potent protection against wild-type virus challenge. We have developed a novel live attenuated (nef deleted) vaccine SIVmac239 (SIVrtTA) that is dependent on doxycycline for replication in vivo. Withdrawal of doxycycline prevents replication of SIVrtTA. We used this virus to vaccinate rhesus macaques to investigate the role of virus replication and persistence in protection against SIVmac239 challenge." @default.
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- W2048772020 date "2009-10-01" @default.
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- W2048772020 title "P03-08. Protection against SIVmac239 challenge in a rhesus macaque model conferred by a doxycycline dependent attenuated SIVmac239" @default.
- W2048772020 doi "https://doi.org/10.1186/1742-4690-6-s3-p25" @default.
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