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- W2048774803 abstract "The structure of the known secondary metabolite β-rubromycin was corrected, based on spectroscopic and chemical investigations, from o-quinone 1 to p-quinone 6. By feeding [U-13C3]malonic acid to the rubromycin-producing strain, Streptomyces sp. A1, the polyketide origin of the skeleton was verified, but the identity of the starter unit and the folding mechanism of the polyketide chain are still unclear. From the culture broth of the strain A1, in addition to 6, the co-metabolites γ-rubromycin (3), δ-rubromycin (4) and 3′-hydroxy-β-rubromycin (7) were isolated. Their structures were determined or confirmed by detailed spectroscopic analysis. The rubromycins inhibit HIV-1 reverse transcriptase (RT) and are cytostatically active against different tumor cell lines." @default.
- W2048774803 created "2016-06-24" @default.
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- W2048774803 date "2000-03-01" @default.
- W2048774803 modified "2023-09-27" @default.
- W2048774803 title "Structural and Biosynthetic Investigations of the Rubromycins" @default.
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- W2048774803 doi "https://doi.org/10.1002/(sici)1099-0690(200003)2000:5<729::aid-ejoc729>3.0.co;2-2" @default.
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