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- W2048776061 abstract "A series of 3,6-disubstituted acridine derivatives have been rationally designed as telomerase inhibitors. They have been designed on the basis that inhibition of telomerase occurs by stabilising G-quadruplex structures formed by the folding of telomeric DNA. The most potent inhibitors have IC50 values against telomerase of between 1.3 and 8 microM, comparable to their cytotoxicity in ovarian cancer cell lines." @default.
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- W2048776061 date "1999-09-01" @default.
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- W2048776061 title "Human telomerase inhibition by substituted acridine derivatives" @default.
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- W2048776061 doi "https://doi.org/10.1016/s0960-894x(99)00394-7" @default.
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