FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048776432> ?p ?o ?g. }

• W2048776432 endingPage "G479" @default.
• W2048776432 startingPage "G471" @default.
• W2048776432 abstract "Alcohol consumption is a major risk factor accelerating the progression of liver disease in patients with chronic hepatitis virus infection. However, the mechanism underlying the enhanced susceptibility of alcoholics to liver injury is not fully understood. Here, we demonstrate that chronic ethanol consumption increases the susceptibility of C57BL/6 mice to concanavalin A (Con A)-induced T cell-mediated hepatitis. Injection of a low dose of Con A (5 μg/g) causes severe liver damage in ethanol-fed mice as evidenced by a significant elevation of serum alanine aminotransaminase levels, massive necrosis, and infiltration of leukocytes but only slightly induces liver injury in control pair-fed mice. In ethanol-fed mice, the activation and cytotoxicity of natural killer T cells, cells that play key roles in Con A-induced T cell hepatitis, are not significantly enhanced relative to pair-fed mice. Moreover, Con A-induced activation of hepatic NF-κB is increased, whereas activation of STAT1 and STAT3 is attenuated in ethanol-fed mice. Consistent with this result, the expression of chemokines and adhesion molecules [such as ICAM-1, macrophage inflammatory protein (MIP)-1, MIP-2, and MCP-1] controlled by NF-κB is upregulated, whereas STAT1-controlled expression of chemokines (such as MIG and IP-10) is downregulated in ethanol-fed mice compared with pair-fed mice. In conclusion, chronic alcohol consumption accelerates T cell-mediated hepatitis via upregulation of the NF-κB signaling pathway and subsequently enhances expression of chemokines/adhesive molecules and recruitment of leukocytes into the liver. Downregulation of the antiapoptotic STAT3 signal may also contribute to alcohol potentiation of T cell hepatitis." @default.
• W2048776432 created "2016-06-24" @default.
• W2048776432 creator A5022234390 @default.
• W2048776432 creator A5031953660 @default.
• W2048776432 creator A5041353057 @default.
• W2048776432 creator A5063090940 @default.
• W2048776432 creator A5077287945 @default.
• W2048776432 creator A5077438329 @default.
• W2048776432 date "2004-08-01" @default.
• W2048776432 modified "2023-10-17" @default.
• W2048776432 title "Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-κB and STAT3 signaling pathways" @default.
• W2048776432 cites W1485185791 @default.
• W2048776432 cites W1566461421 @default.
• W2048776432 cites W1856085327 @default.
• W2048776432 cites W1874222778 @default.
• W2048776432 cites W1966771241 @default.
• W2048776432 cites W1967350641 @default.
• W2048776432 cites W1968213123 @default.
• W2048776432 cites W1968261026 @default.
• W2048776432 cites W1977250424 @default.
• W2048776432 cites W1985386845 @default.
• W2048776432 cites W1987160791 @default.
• W2048776432 cites W1990938548 @default.
• W2048776432 cites W2000691137 @default.
• W2048776432 cites W2003747312 @default.
• W2048776432 cites W2004592086 @default.
• W2048776432 cites W2009522235 @default.
• W2048776432 cites W2009914744 @default.
• W2048776432 cites W2010108646 @default.
• W2048776432 cites W2021188450 @default.
• W2048776432 cites W2028161109 @default.
• W2048776432 cites W2036015712 @default.
• W2048776432 cites W2036836249 @default.
• W2048776432 cites W2038805818 @default.
• W2048776432 cites W2041729389 @default.
• W2048776432 cites W2041936765 @default.
• W2048776432 cites W2055685227 @default.
• W2048776432 cites W2072920601 @default.
• W2048776432 cites W2077147853 @default.
• W2048776432 cites W2082726181 @default.
• W2048776432 cites W2087918350 @default.
• W2048776432 cites W2095005655 @default.
• W2048776432 cites W2097033993 @default.
• W2048776432 cites W2097139406 @default.
• W2048776432 cites W2099741663 @default.
• W2048776432 cites W2104584260 @default.
• W2048776432 cites W2128372435 @default.
• W2048776432 cites W2139979263 @default.
• W2048776432 cites W2147700544 @default.
• W2048776432 cites W2154851868 @default.
• W2048776432 cites W2184882025 @default.
• W2048776432 cites W2321120966 @default.
• W2048776432 cites W4231718235 @default.
• W2048776432 cites W4238652665 @default.
• W2048776432 cites W4240670890 @default.
• W2048776432 cites W4244619221 @default.
• W2048776432 cites W4246233276 @default.
• W2048776432 doi "https://doi.org/10.1152/ajpgi.00018.2004" @default.
• W2048776432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15064234" @default.
• W2048776432 hasPublicationYear "2004" @default.
• W2048776432 type Work @default.
• W2048776432 sameAs 2048776432 @default.
• W2048776432 citedByCount "47" @default.
• W2048776432 countsByYear W20487764322012 @default.
• W2048776432 countsByYear W20487764322013 @default.
• W2048776432 countsByYear W20487764322015 @default.
• W2048776432 countsByYear W20487764322016 @default.
• W2048776432 countsByYear W20487764322017 @default.
• W2048776432 countsByYear W20487764322018 @default.
• W2048776432 countsByYear W20487764322019 @default.
• W2048776432 countsByYear W20487764322020 @default.
• W2048776432 countsByYear W20487764322021 @default.
• W2048776432 countsByYear W20487764322023 @default.
• W2048776432 crossrefType "journal-article" @default.
• W2048776432 hasAuthorship W2048776432A5022234390 @default.
• W2048776432 hasAuthorship W2048776432A5031953660 @default.
• W2048776432 hasAuthorship W2048776432A5041353057 @default.
• W2048776432 hasAuthorship W2048776432A5063090940 @default.
• W2048776432 hasAuthorship W2048776432A5077287945 @default.
• W2048776432 hasAuthorship W2048776432A5077438329 @default.
• W2048776432 hasConcept C104317684 @default.
• W2048776432 hasConcept C126322002 @default.
• W2048776432 hasConcept C127561419 @default.
• W2048776432 hasConcept C13373296 @default.
• W2048776432 hasConcept C134018914 @default.
• W2048776432 hasConcept C17991360 @default.
• W2048776432 hasConcept C185592680 @default.
• W2048776432 hasConcept C203014093 @default.
• W2048776432 hasConcept C2776637226 @default.
• W2048776432 hasConcept C2776914184 @default.
• W2048776432 hasConcept C2777214474 @default.
• W2048776432 hasConcept C2777575235 @default.
• W2048776432 hasConcept C2778923194 @default.
• W2048776432 hasConcept C2780732942 @default.
• W2048776432 hasConcept C502942594 @default.
• W2048776432 hasConcept C55493867 @default.
• W2048776432 hasConcept C62478195 @default.
• W2048776432 hasConcept C71924100 @default.

• next