FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048780334> ?p ?o ?g. }

• W2048780334 endingPage "788" @default.
• W2048780334 startingPage "775" @default.
• W2048780334 abstract "Background RSC is a chromatin-remodelling complex of Saccharomyces cerevisiae and essential for growth. Its catalytic subunit is encoded by the NPS1/STH1 gene. At the present time, little is known regarding the cellular function of RSC. Results To identify genes with functions related to NPS1, we screened high-copy suppressor genes for the temperature- and thiabendazole (TBZ)-sensitive mutant allele of NPS1, nps1-105. Amongst the suppressors we cloned PKC1/STT1 and BIM1 that encoded a homologue of mammalian protein kinase C and a conserved microtubule binding protein homologous to human EB1, respectively. Both the temperature sensitive mutation of PKC1, stt1, and the bim1 null mutation caused synthetic growth defects with nps1-105. A genetic analysis of the functional relationships between these genes revealed that PKC1 suppressed the defect of nps1-105 through the BIM1 function but not by the activation of the MPK1/MAPK pathway. The stt1 mutation alone showed TBZ sensitivity and delayed the G2-phase progression at semi-permissive temperatures. Both of these stt1 phenotypes were suppressed by the over-expression of BIM1. In addition, stt1 as well as nps1-105, mis-segregated a mini-chromosome at frequencies higher than the wild-type at a permissive temperature. The mis-segregation was enhanced in the nps1-105 stt1 double mutant. Conclusion These results suggest that Pkc1p plays a role which is relevant to microtubule functions and that this role is mediated by a hitherto unknown PKC signalling pathway and by Bim1p" @default.
• W2048780334 created "2016-06-24" @default.
• W2048780334 creator A5010672226 @default.
• W2048780334 creator A5016658824 @default.
• W2048780334 creator A5058278032 @default.
• W2048780334 creator A5060494951 @default.
• W2048780334 creator A5086004105 @default.
• W2048780334 date "2001-09-01" @default.
• W2048780334 modified "2023-09-27" @default.
• W2048780334 title "<i>PKC1</i>, a protein kinase C homologue of<i>Saccharomyces cerevisiae</i>, participates in microtubule function through the yeast EB1 homologue,<i>BIM1</i>" @default.
• W2048780334 cites W1499601028 @default.
• W2048780334 cites W1536878050 @default.
• W2048780334 cites W1570075445 @default.
• W2048780334 cites W1631868599 @default.
• W2048780334 cites W1638042144 @default.
• W2048780334 cites W1695245462 @default.
• W2048780334 cites W1798150371 @default.
• W2048780334 cites W1864334043 @default.
• W2048780334 cites W1871617923 @default.
• W2048780334 cites W1889502940 @default.
• W2048780334 cites W1929568320 @default.
• W2048780334 cites W1967988752 @default.
• W2048780334 cites W1978705545 @default.
• W2048780334 cites W1989819187 @default.
• W2048780334 cites W1995645000 @default.
• W2048780334 cites W1997206295 @default.
• W2048780334 cites W2017619665 @default.
• W2048780334 cites W2040518083 @default.
• W2048780334 cites W2054836163 @default.
• W2048780334 cites W2064787601 @default.
• W2048780334 cites W2071468845 @default.
• W2048780334 cites W2080229333 @default.
• W2048780334 cites W2096421037 @default.
• W2048780334 cites W2099661865 @default.
• W2048780334 cites W2101357707 @default.
• W2048780334 cites W2104509794 @default.
• W2048780334 cites W2106176503 @default.
• W2048780334 cites W2112587640 @default.
• W2048780334 cites W2113997447 @default.
• W2048780334 cites W2116730865 @default.
• W2048780334 cites W2123150152 @default.
• W2048780334 cites W2136891997 @default.
• W2048780334 cites W2140510083 @default.
• W2048780334 cites W2143924086 @default.
• W2048780334 cites W2144725486 @default.
• W2048780334 cites W2147808841 @default.
• W2048780334 cites W2159135766 @default.
• W2048780334 cites W304139261 @default.
• W2048780334 cites W4247323657 @default.
• W2048780334 cites W4255361277 @default.
• W2048780334 doi "https://doi.org/10.1046/j.1365-2443.2001.00461.x" @default.
• W2048780334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11554924" @default.
• W2048780334 hasPublicationYear "2001" @default.
• W2048780334 type Work @default.
• W2048780334 sameAs 2048780334 @default.
• W2048780334 citedByCount "24" @default.
• W2048780334 countsByYear W20487803342012 @default.
• W2048780334 countsByYear W20487803342013 @default.
• W2048780334 countsByYear W20487803342014 @default.
• W2048780334 countsByYear W20487803342015 @default.
• W2048780334 countsByYear W20487803342016 @default.
• W2048780334 crossrefType "journal-article" @default.
• W2048780334 hasAuthorship W2048780334A5010672226 @default.
• W2048780334 hasAuthorship W2048780334A5016658824 @default.
• W2048780334 hasAuthorship W2048780334A5058278032 @default.
• W2048780334 hasAuthorship W2048780334A5060494951 @default.
• W2048780334 hasAuthorship W2048780334A5086004105 @default.
• W2048780334 hasConcept C104292427 @default.
• W2048780334 hasConcept C104317684 @default.
• W2048780334 hasConcept C143065580 @default.
• W2048780334 hasConcept C14519417 @default.
• W2048780334 hasConcept C153911025 @default.
• W2048780334 hasConcept C167227067 @default.
• W2048780334 hasConcept C184235292 @default.
• W2048780334 hasConcept C20418707 @default.
• W2048780334 hasConcept C2777576037 @default.
• W2048780334 hasConcept C501734568 @default.
• W2048780334 hasConcept C54355233 @default.
• W2048780334 hasConcept C57708383 @default.
• W2048780334 hasConcept C83640560 @default.
• W2048780334 hasConcept C86803240 @default.
• W2048780334 hasConcept C97029542 @default.
• W2048780334 hasConceptScore W2048780334C104292427 @default.
• W2048780334 hasConceptScore W2048780334C104317684 @default.
• W2048780334 hasConceptScore W2048780334C143065580 @default.
• W2048780334 hasConceptScore W2048780334C14519417 @default.
• W2048780334 hasConceptScore W2048780334C153911025 @default.
• W2048780334 hasConceptScore W2048780334C167227067 @default.
• W2048780334 hasConceptScore W2048780334C184235292 @default.
• W2048780334 hasConceptScore W2048780334C20418707 @default.
• W2048780334 hasConceptScore W2048780334C2777576037 @default.
• W2048780334 hasConceptScore W2048780334C501734568 @default.
• W2048780334 hasConceptScore W2048780334C54355233 @default.
• W2048780334 hasConceptScore W2048780334C57708383 @default.
• W2048780334 hasConceptScore W2048780334C83640560 @default.
• W2048780334 hasConceptScore W2048780334C86803240 @default.
• W2048780334 hasConceptScore W2048780334C97029542 @default.
• W2048780334 hasIssue "9" @default.

• next