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• W2048785655 startingPage "145" @default.
• W2048785655 abstract "Oxygen supply into inside solid tumor is often diminished, which is called hypoxia. Many gene transcriptions were activated by hypoxia-inducible factor (HIF)-<TEX>$1{alpha}$</TEX>. Here, we investigated the effect of hypoxia on paclitaxel-resistance induction in HeLa cervical tumor cells. When HeLa cells were incubated under hypoxia condition, HIF-<TEX>$1{alpha}$</TEX> level was increased. In contrast, paclitaxel-mediated tumor cell death was reduced by the incubation under hypoxia condition. Paclitaxel-mediated tumor cell death was also inhibited by treatment with DMOG, chemical HIF-<TEX>$1{alpha}$</TEX> stabilizer, in a dose-dependent manner. A significant increase in intracellular ROS level was detected by the incubation under hypoxia condition. A basal level of cell density was increased in response to 10 nM <TEX>$H_2O_2$</TEX>. HIF-<TEX>$1{alpha}$</TEX> level was increased by treatment with various concentration of <TEX>$H_2O_2$</TEX>. The increased level of HIF-<TEX>$1{alpha}$</TEX> by hypoxia was reduced by the treatment with N-acetylcysteine (NAC), a well-known ROS scavenger. Paclitaxel-mediated tumor cell death was increased by treatment with NAC. Taken together, these findings demonstrate that hypoxia could play a role in paclitaxel-resistance induction through ROS-mediated HIF-<TEX>$1{alpha}$</TEX> stabilization. These results suggest that hypoxia-induced ROS could, in part, control tumor cell death through an increase in HIF-<TEX>$1{alpha}$</TEX> level." @default.
• W2048785655 created "2016-06-24" @default.
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• W2048785655 date "2010-04-30" @default.
• W2048785655 modified "2023-10-17" @default.
• W2048785655 title "Hypoxia Induces Paclitaxel-Resistance through ROS Production" @default.
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• W2048785655 doi "https://doi.org/10.4062/biomolther.2010.18.2.145" @default.
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