FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048792298> ?p ?o ?g. }

• W2048792298 endingPage "387" @default.
• W2048792298 startingPage "378" @default.
• W2048792298 abstract "In this study, we investigated whether the enaminone, E121, has anti-tussive effects in a guinea pig model of cough, and if so, whether this effect is mediated via a central or peripheral site of action. We also assessed whether E121 has bronchodilator effects and the molecular mechanisms underlying any anti-tussive and/or bronchodilator effects.Whole body plethysmography was used to assess both cough and airway obstruction. A stereotaxic apparatus was used to administer drugs intracerebroventricularly (i.c.v.). Effects of E121 were examined in vitro on contractile effects in guinea pig bronchioles.Pre-treatment of animals with E121 resulted in a significant inhibition in the citric acid-induced cough and airway obstruction compared to vehicle-pretreated animals. The K(ATP) antagonist, glibenclamide, significantly inhibited the anti-tussive and bronchoprotective effects of E121. Also, intra-tracheal administration of E121 resulted in a significant inhibition of both the citric acid-induced cough response and airway obstruction compared to vehicle-pretreated animals. By contrast, i.c.v. administration had no effect. Finally, E121 significantly inhibited carbachol-induced airway smooth muscle contractions, an effect that was reduced by both glibenclamide and propranolol. Interestingly, E121 enhanced histamine-induced cAMP release in human eosinophils although it did not directly elevate cAMP levels.The enaminone, E121, has anti-tussive and bronchodilatory effects and is topically, but not centrally, active. The anti-tussive mechanism of action of E121 seems to be K(ATP) channel dependent, whereas its bronchodilatory effects appear to be mediated via activation of both K(ATP) channels and β(2) receptors. Therefore, E121 may potentially represent a novel therapy for cough, particularly cough associated with airway obstruction." @default.
• W2048792298 created "2016-06-24" @default.
• W2048792298 creator A5009707260 @default.
• W2048792298 creator A5014218777 @default.
• W2048792298 creator A5041313393 @default.
• W2048792298 creator A5062833068 @default.
• W2048792298 creator A5065967997 @default.
• W2048792298 creator A5072913462 @default.
• W2048792298 date "2011-09-01" @default.
• W2048792298 modified "2023-10-16" @default.
• W2048792298 title "Anti-tussive and bronchodilator mechanisms of action for the enaminone E121" @default.
• W2048792298 cites W1561513264 @default.
• W2048792298 cites W1642903380 @default.
• W2048792298 cites W1926578427 @default.
• W2048792298 cites W1971704495 @default.
• W2048792298 cites W1977837017 @default.
• W2048792298 cites W1988958406 @default.
• W2048792298 cites W1993300898 @default.
• W2048792298 cites W1994333538 @default.
• W2048792298 cites W1994663666 @default.
• W2048792298 cites W1996309612 @default.
• W2048792298 cites W1998465460 @default.
• W2048792298 cites W2000444833 @default.
• W2048792298 cites W2003396780 @default.
• W2048792298 cites W2005179275 @default.
• W2048792298 cites W2011118799 @default.
• W2048792298 cites W2013706697 @default.
• W2048792298 cites W2016213211 @default.
• W2048792298 cites W2017417294 @default.
• W2048792298 cites W2017749497 @default.
• W2048792298 cites W2029863675 @default.
• W2048792298 cites W2037968315 @default.
• W2048792298 cites W2049215234 @default.
• W2048792298 cites W2049424588 @default.
• W2048792298 cites W2051939900 @default.
• W2048792298 cites W2052874576 @default.
• W2048792298 cites W2054139954 @default.
• W2048792298 cites W2054635732 @default.
• W2048792298 cites W2055465706 @default.
• W2048792298 cites W2055899156 @default.
• W2048792298 cites W2057685174 @default.
• W2048792298 cites W2060277399 @default.
• W2048792298 cites W2064239907 @default.
• W2048792298 cites W2067290345 @default.
• W2048792298 cites W2073747237 @default.
• W2048792298 cites W2076244488 @default.
• W2048792298 cites W2091511753 @default.
• W2048792298 cites W2103052624 @default.
• W2048792298 cites W2106072474 @default.
• W2048792298 cites W2111745101 @default.
• W2048792298 cites W2114756811 @default.
• W2048792298 cites W2118045590 @default.
• W2048792298 cites W2120707820 @default.
• W2048792298 cites W2131958728 @default.
• W2048792298 cites W2167834377 @default.
• W2048792298 cites W2949652215 @default.
• W2048792298 cites W2950858596 @default.
• W2048792298 doi "https://doi.org/10.1016/j.lfs.2011.07.007" @default.
• W2048792298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21798272" @default.
• W2048792298 hasPublicationYear "2011" @default.
• W2048792298 type Work @default.
• W2048792298 sameAs 2048792298 @default.
• W2048792298 citedByCount "23" @default.
• W2048792298 countsByYear W20487922982012 @default.
• W2048792298 countsByYear W20487922982013 @default.
• W2048792298 countsByYear W20487922982014 @default.
• W2048792298 countsByYear W20487922982015 @default.
• W2048792298 countsByYear W20487922982016 @default.
• W2048792298 countsByYear W20487922982017 @default.
• W2048792298 countsByYear W20487922982018 @default.
• W2048792298 countsByYear W20487922982019 @default.
• W2048792298 countsByYear W20487922982020 @default.
• W2048792298 countsByYear W20487922982021 @default.
• W2048792298 crossrefType "journal-article" @default.
• W2048792298 hasAuthorship W2048792298A5009707260 @default.
• W2048792298 hasAuthorship W2048792298A5014218777 @default.
• W2048792298 hasAuthorship W2048792298A5041313393 @default.
• W2048792298 hasAuthorship W2048792298A5062833068 @default.
• W2048792298 hasAuthorship W2048792298A5065967997 @default.
• W2048792298 hasAuthorship W2048792298A5072913462 @default.
• W2048792298 hasConcept C1122143 @default.
• W2048792298 hasConcept C126322002 @default.
• W2048792298 hasConcept C134018914 @default.
• W2048792298 hasConcept C170493617 @default.
• W2048792298 hasConcept C185592680 @default.
• W2048792298 hasConcept C202751555 @default.
• W2048792298 hasConcept C24998067 @default.
• W2048792298 hasConcept C2776042228 @default.
• W2048792298 hasConcept C2776120743 @default.
• W2048792298 hasConcept C2776371117 @default.
• W2048792298 hasConcept C2776885963 @default.
• W2048792298 hasConcept C2778815084 @default.
• W2048792298 hasConcept C2778988552 @default.
• W2048792298 hasConcept C2779768347 @default.
• W2048792298 hasConcept C2781018748 @default.
• W2048792298 hasConcept C42219234 @default.
• W2048792298 hasConcept C55493867 @default.
• W2048792298 hasConcept C555293320 @default.

• next