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• W2048792359 abstract "We have identified a novel mouse Wnt gene using a cDNA differential screening procedure for retinoic-acid-induced transcripts in P19 embryonal carcinoma cells. Sequence analysis showed that this gene represents the first murine Wnt-8 (mWnt-8) gene reported to date. The expression of the mWnt-8 gene, which is rapidly induced by retinoic acid in P19 and embryonic stem cells, appears to be restricted to early stages of mouse embryogenesis, mWnt-8 transcripts are first detected in the posterior region of the epiblast of early primitive streak-stage embryos. As gastrulation proceeds, mWnt-8 expression spreads into the embryonic ectoderm up to a sharp rostral boundary at the base of the developing headfolds.mWnt-8 is also transiently expressed in the newly formed mesoderm.mWnt-8 expression is rapidly down-regulated during early somitogenesis, the latest detectable expression domains corresponding to the presumptive fourth rhombomere and the caudal region of the neural plate. The expression pattern of mWnt-8 is clearly distinct from those of other murine Wnt genes expressed during gastrulation, but shows striking similarities with that of the chicken Cwnt-8C gene. We also show that mWnt-8 expression is ectopically induced in the rostral neural plate in response to RA exposure of presomitic (7ȁ7.5 days post coitum) cultured mouse embryos." @default.
• W2048792359 created "2016-06-24" @default.
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• W2048792359 date "1996-08-01" @default.
• W2048792359 modified "2023-09-24" @default.
• W2048792359 title "A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid" @default.
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• W2048792359 doi "https://doi.org/10.1016/s0925-4773(96)00569-2" @default.
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