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- W2048793397 abstract "Changes in the dorsal root ganglion (DRG) expression of the sodium channels Na v 1.8 and Na v 1.9 may contribute to injury-induced hyperexcitability and pain. Interferon (IFN)-γ receptor −/− mice display a reduced pain-related behavior after nerve injury as compared to wild-type mice (NeuroReport 8 (1997) 1311). To elucidate a possible role for IFN-γ in the regulation of sodium channels, we have studied the DRG mRNA expression of Na v 1.8/Na v 1.9 in IFN-γ- or IFN-γ receptor-deficient mice. In both types of mice, nerve damage induced a downregulation of Na v 1.8 as well as Na v 1.9. The magnitude of this reduction was similar to that observed in wild-type animals. These results indicate that the downregulation of Na v 1.8/Na v 1.9 in damaged DRG neurons is not influenced by IFN-γ. Thus, the reduced pain-related behavior of nerve-injured IFN-γ receptor null mice is not due to differential changes in the regulation of Na v 1.8/Na v 1.9 mRNA." @default.
- W2048793397 created "2016-06-24" @default.
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- W2048793397 date "2003-03-01" @default.
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- W2048793397 title "Expression of the sodium channel transcripts Nav1.8 and Nav1.9 in injured dorsal root ganglion neurons of interferon-γ or interferon-γ receptor deficient mice" @default.
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- W2048793397 doi "https://doi.org/10.1016/s0304-3940(02)01407-6" @default.
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