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- W2048801047 abstract "Epidemiological evidence indicates that ingestion of alcoholic beverages is a risk factor or is associated with a risk factor for breast cancer. A small increase in relative risk (1.1–1.2) compared to non-drinkers, has been reported for drinkers of small amounts of alcohol, approximately 3–4 drinks per week; a larger increase in relative risk (1.4–1.7) with a significant dose relationship occurs at intakes of 2–3 drinks per day. Two drinks per day would supply approximately 7–10% of a woman's caloric intake. This evidence, coupled with the general association of breast cancer risk with higher economic, nutritional and education status, supports the view that relevant animal models for study of the relationship between alcohol and breast cancer should employ moderate alcohol and good nutrient intake. Two carcinogenesis experiments were performed in ethanolfed, female, Sprague-Dawley rats. In the first, groups of 50 rats were fed control diet ad libitum (CON) or were fed the diet with 20% of calories supplied as ethanol (ETOH) or intake of ETOH rats (PF). They were given 7, 12-dimethylbenzanthracene (DMBA), 20 mg/kg, by gavage at 55 days of age and monitored for tumor development. There was no detectable effect of ethanol on mammary tumor latency, incidence, number, weight or histology. In the second experiment, rats divided into the same groups were given 25% and the dose of DMBA was increased to 30 mg/kg. Again, there was no detectable effect of ethanol on mammary tumorigenesis. Thus, no effect of ethanol on mammary gland tumorigenesis by DMBA was observed in rats treated by 2 different protocols." @default.
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- W2048801047 date "1990-08-01" @default.
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- W2048801047 title "Dimethylbenzanthracene-induced mammary tumorigenesis in ethanol-fed rats" @default.
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- W2048801047 doi "https://doi.org/10.1016/s0271-5317(05)80055-7" @default.
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