FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048801631> ?p ?o ?g. }

• W2048801631 endingPage "289" @default.
• W2048801631 startingPage "281" @default.
• W2048801631 abstract "Topical corticosteroids (TCS) are among the most frequently used topical therapeutics. Recently, it has been shown that TCS not only has antiproliferative actions, but also inhibits the differentiation of the epidermis and finally perturbates stratum corneum (SC) barrier function. It is well established that epidermal barrier function resides within the intercellular lipids of the SC. However, to date, little is known about the effects of TCS on the structure and composition of SC lipids. We therefore used hairless mouse skin to study the sequential changes of the SC permeability barrier and their intercellular lipids by ruthenium tetroxide staining and high-performance thin-layer chromatography (HPTLC) during topical use of corticosteroids. The results demonstrated a progressive increase in transepidermal water loss accompanied by a diminution in the SC intercellular lipid lamellae, which showed a normal structure of individual lamella. Analysis of lipid composition by HPTLC after a 6-week application of TCS also showed an obvious decrease in all the main components of SC lipids, which are known to constitute the permeability barrier of the skin. In light of these results, our work provides direct morphological evidence that TCS deteriorates the permeability barrier of epidermis when applied to normal skin." @default.
• W2048801631 created "2016-06-24" @default.
• W2048801631 creator A5012870190 @default.
• W2048801631 creator A5034048153 @default.
• W2048801631 creator A5057384994 @default.
• W2048801631 creator A5063862589 @default.
• W2048801631 date "1998-05-01" @default.
• W2048801631 modified "2023-10-12" @default.
• W2048801631 title "Permeability Barrier Abnormality of Hairless Mouse Epidermis after Topical Corticosteroid: Characterization of Stratum Corneum Lipids by Ruthenium Tetroxide Staining and High-Performance Thin-Layer Chromatography" @default.
• W2048801631 cites W1872675327 @default.
• W2048801631 cites W1965035131 @default.
• W2048801631 cites W1967102600 @default.
• W2048801631 cites W1969893312 @default.
• W2048801631 cites W1974994627 @default.
• W2048801631 cites W2000819908 @default.
• W2048801631 cites W2020372857 @default.
• W2048801631 cites W2033921570 @default.
• W2048801631 cites W2036867658 @default.
• W2048801631 cites W2072062048 @default.
• W2048801631 cites W2073074765 @default.
• W2048801631 cites W2076964588 @default.
• W2048801631 cites W2084302733 @default.
• W2048801631 cites W2126394796 @default.
• W2048801631 cites W2133777985 @default.
• W2048801631 cites W2152311269 @default.
• W2048801631 cites W2166021357 @default.
• W2048801631 cites W2303771534 @default.
• W2048801631 cites W2340018524 @default.
• W2048801631 cites W2410008372 @default.
• W2048801631 cites W2440583568 @default.
• W2048801631 cites W4246102039 @default.
• W2048801631 cites W4247896468 @default.
• W2048801631 cites W4299948123 @default.
• W2048801631 doi "https://doi.org/10.1111/j.1346-8138.1998.tb02399.x" @default.
• W2048801631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9640880" @default.
• W2048801631 hasPublicationYear "1998" @default.
• W2048801631 type Work @default.
• W2048801631 sameAs 2048801631 @default.
• W2048801631 citedByCount "32" @default.
• W2048801631 countsByYear W20488016312012 @default.
• W2048801631 countsByYear W20488016312014 @default.
• W2048801631 countsByYear W20488016312015 @default.
• W2048801631 countsByYear W20488016312019 @default.
• W2048801631 countsByYear W20488016312021 @default.
• W2048801631 crossrefType "journal-article" @default.
• W2048801631 hasAuthorship W2048801631A5012870190 @default.
• W2048801631 hasAuthorship W2048801631A5034048153 @default.
• W2048801631 hasAuthorship W2048801631A5057384994 @default.
• W2048801631 hasAuthorship W2048801631A5063862589 @default.
• W2048801631 hasConcept C105702510 @default.
• W2048801631 hasConcept C120882062 @default.
• W2048801631 hasConcept C12554922 @default.
• W2048801631 hasConcept C142724271 @default.
• W2048801631 hasConcept C185592680 @default.
• W2048801631 hasConcept C2776458125 @default.
• W2048801631 hasConcept C2778370115 @default.
• W2048801631 hasConcept C2779156968 @default.
• W2048801631 hasConcept C41625074 @default.
• W2048801631 hasConcept C51911345 @default.
• W2048801631 hasConcept C55493867 @default.
• W2048801631 hasConcept C71924100 @default.
• W2048801631 hasConcept C74864618 @default.
• W2048801631 hasConcept C86803240 @default.
• W2048801631 hasConcept C95150158 @default.
• W2048801631 hasConcept C95444343 @default.
• W2048801631 hasConceptScore W2048801631C105702510 @default.
• W2048801631 hasConceptScore W2048801631C120882062 @default.
• W2048801631 hasConceptScore W2048801631C12554922 @default.
• W2048801631 hasConceptScore W2048801631C142724271 @default.
• W2048801631 hasConceptScore W2048801631C185592680 @default.
• W2048801631 hasConceptScore W2048801631C2776458125 @default.
• W2048801631 hasConceptScore W2048801631C2778370115 @default.
• W2048801631 hasConceptScore W2048801631C2779156968 @default.
• W2048801631 hasConceptScore W2048801631C41625074 @default.
• W2048801631 hasConceptScore W2048801631C51911345 @default.
• W2048801631 hasConceptScore W2048801631C55493867 @default.
• W2048801631 hasConceptScore W2048801631C71924100 @default.
• W2048801631 hasConceptScore W2048801631C74864618 @default.
• W2048801631 hasConceptScore W2048801631C86803240 @default.
• W2048801631 hasConceptScore W2048801631C95150158 @default.
• W2048801631 hasConceptScore W2048801631C95444343 @default.
• W2048801631 hasIssue "5" @default.
• W2048801631 hasLocation W20488016311 @default.
• W2048801631 hasLocation W20488016312 @default.
• W2048801631 hasOpenAccess W2048801631 @default.
• W2048801631 hasPrimaryLocation W20488016311 @default.
• W2048801631 hasRelatedWork W187845116 @default.
• W2048801631 hasRelatedWork W1969687658 @default.
• W2048801631 hasRelatedWork W1974160443 @default.
• W2048801631 hasRelatedWork W1994252498 @default.
• W2048801631 hasRelatedWork W2004804813 @default.
• W2048801631 hasRelatedWork W2015490928 @default.
• W2048801631 hasRelatedWork W2324639233 @default.
• W2048801631 hasRelatedWork W3013090455 @default.
• W2048801631 hasRelatedWork W4318947496 @default.
• W2048801631 hasRelatedWork W4322744585 @default.
• W2048801631 hasVolume "25" @default.
• W2048801631 isParatext "false" @default.

• next