FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048808569> ?p ?o ?g. }

• W2048808569 endingPage "3179" @default.
• W2048808569 startingPage "3165" @default.
• W2048808569 abstract "Epigenetic differences exist between trauma-exposed individuals with and without post-traumatic stress disorder (PTSD). It is unclear whether these epigenetic differences pre-exist, or arise following, trauma and PTSD onset.In pre- and post-trauma samples from a subset of Detroit Neighborhood Health Study participants, DNA methylation (DNAm) was measured at DNA methyltransferase 1 (DNMT1), DNMT3A, DNMT3B and DNMT3L. Pre-trauma DNAm differences and changes in DNAm from pre- to post-trauma were assessed between and within PTSD cases (n = 30) and age-, gender- and trauma exposure-matched controls (n = 30). Pre-trauma DNAm was tested for association with post-trauma symptom severity (PTSS) change. Potential functional consequences of DNAm differences were explored via bioinformatic search for putative transcription factor binding sites (TFBS).DNMT1 DNAm increased following trauma in PTSD cases (p = 0.001), but not controls (p = 0.067). DNMT3A and DNMT3B DNAm increased following trauma in both cases (DNMT3A: p = 0.009; DNMT3B: p < 0.001) and controls (DNMT3A: p = 0.002; DNMT3B: p < 0.001). In cases only, pre-trauma DNAm was lower at a DNMT3B CpG site that overlaps with a TFBS involved in epigenetic regulation (p = 0.001); lower pre-trauma DNMT3B DNAm at this site was predictive of worsening of PTSS post-trauma (p = 0.034). Some effects were attenuated following correction for multiple hypothesis testing.DNAm among trauma-exposed individuals shows both longitudinal changes and pre-existing epigenetic states that differentiate individuals who are resilient versus susceptible to PTSD. These distinctive DNAm differences within DNMT loci may contribute to genome-wide epigenetic profiles of PTSD." @default.
• W2048808569 created "2016-06-24" @default.
• W2048808569 creator A5013710256 @default.
• W2048808569 creator A5014239873 @default.
• W2048808569 creator A5026464787 @default.
• W2048808569 creator A5031482400 @default.
• W2048808569 creator A5033943476 @default.
• W2048808569 creator A5057264401 @default.
• W2048808569 creator A5064052128 @default.
• W2048808569 date "2014-04-25" @default.
• W2048808569 modified "2023-09-23" @default.
• W2048808569 title "Longitudinal epigenetic variation of DNA methyltransferase genes is associated with vulnerability to post-traumatic stress disorder" @default.
• W2048808569 cites W1506631602 @default.
• W2048808569 cites W1552188683 @default.
• W2048808569 cites W1673514954 @default.
• W2048808569 cites W1721773945 @default.
• W2048808569 cites W1821797507 @default.
• W2048808569 cites W1965703575 @default.
• W2048808569 cites W1977354406 @default.
• W2048808569 cites W1980197198 @default.
• W2048808569 cites W1981354816 @default.
• W2048808569 cites W1981399148 @default.
• W2048808569 cites W1985317881 @default.
• W2048808569 cites W1987071871 @default.
• W2048808569 cites W1995796186 @default.
• W2048808569 cites W1999272870 @default.
• W2048808569 cites W1999833210 @default.
• W2048808569 cites W2014408660 @default.
• W2048808569 cites W2018304597 @default.
• W2048808569 cites W2020113570 @default.
• W2048808569 cites W2021995508 @default.
• W2048808569 cites W2022689242 @default.
• W2048808569 cites W2028514728 @default.
• W2048808569 cites W2029281360 @default.
• W2048808569 cites W2036194871 @default.
• W2048808569 cites W2043014254 @default.
• W2048808569 cites W2043927584 @default.
• W2048808569 cites W2046241907 @default.
• W2048808569 cites W2053901332 @default.
• W2048808569 cites W2055238656 @default.
• W2048808569 cites W2059097951 @default.
• W2048808569 cites W2061554433 @default.
• W2048808569 cites W2062722848 @default.
• W2048808569 cites W2062923679 @default.
• W2048808569 cites W2064943181 @default.
• W2048808569 cites W2068480672 @default.
• W2048808569 cites W2070484728 @default.
• W2048808569 cites W2072289007 @default.
• W2048808569 cites W2072595271 @default.
• W2048808569 cites W2073546855 @default.
• W2048808569 cites W2074264906 @default.
• W2048808569 cites W2076312647 @default.
• W2048808569 cites W2077053535 @default.
• W2048808569 cites W2078166655 @default.
• W2048808569 cites W2078526277 @default.
• W2048808569 cites W2080873999 @default.
• W2048808569 cites W2087119365 @default.
• W2048808569 cites W2089580959 @default.
• W2048808569 cites W2093188241 @default.
• W2048808569 cites W2096151996 @default.
• W2048808569 cites W2097859017 @default.
• W2048808569 cites W2102674249 @default.
• W2048808569 cites W2106622947 @default.
• W2048808569 cites W2111243591 @default.
• W2048808569 cites W2113923169 @default.
• W2048808569 cites W2114214919 @default.
• W2048808569 cites W2115818350 @default.
• W2048808569 cites W2116116525 @default.
• W2048808569 cites W2121417064 @default.
• W2048808569 cites W2128782957 @default.
• W2048808569 cites W2132152083 @default.
• W2048808569 cites W2140594127 @default.
• W2048808569 cites W2141403362 @default.
• W2048808569 cites W2144291844 @default.
• W2048808569 cites W2153550523 @default.
• W2048808569 cites W2154899538 @default.
• W2048808569 cites W2155236768 @default.
• W2048808569 cites W2155389918 @default.
• W2048808569 cites W2156626022 @default.
• W2048808569 cites W2160978870 @default.
• W2048808569 cites W2165879373 @default.
• W2048808569 cites W2165964254 @default.
• W2048808569 cites W2166401337 @default.
• W2048808569 cites W2170760271 @default.
• W2048808569 cites W4249129794 @default.
• W2048808569 cites W4254108335 @default.
• W2048808569 doi "https://doi.org/10.1017/s0033291714000968" @default.
• W2048808569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4530981" @default.
• W2048808569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25065861" @default.
• W2048808569 hasPublicationYear "2014" @default.
• W2048808569 type Work @default.
• W2048808569 sameAs 2048808569 @default.
• W2048808569 citedByCount "45" @default.
• W2048808569 countsByYear W20488085692014 @default.
• W2048808569 countsByYear W20488085692015 @default.
• W2048808569 countsByYear W20488085692016 @default.
• W2048808569 countsByYear W20488085692017 @default.
• W2048808569 countsByYear W20488085692018 @default.

• next