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- W2048809904 abstract "Suicide occurs during depression, schizophrenia, diabetes and epilepsy. A common denominator of these disorders is the presence of inflammation. Inflammatory cytokines affect function and expression of the glial enzyme glutamine synthetase and post mortem studies indicate that brain glutamine synthetase function is suppressed in mood disorders and epilepsy. In a study of schizophrenia brains, the expression of glutamine synthetase was reduced in those cases where the cause of death was suicide. The glycogen synthase kinase 3 (GSK3) inhibitor, lithium, which has a proven efficacy against suicide, increased in an animal experiment the expression of glutamine synthetase. Based on these data one could reason that suicide may be prevented by centrally acting GSK3 inhibitors. However, since inhibition of glutamine synthetase may lead to a deficit in glutamine and as consequence a GABA and glutamate deficit, even simple food supplementation with glutamine might help to reduce suicide." @default.
- W2048809904 created "2016-06-24" @default.
- W2048809904 creator A5032330352 @default.
- W2048809904 date "2011-06-01" @default.
- W2048809904 modified "2023-10-06" @default.
- W2048809904 title "Circumstantial evidence for a role of glutamine-synthetase in suicide" @default.
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- W2048809904 doi "https://doi.org/10.1016/j.mehy.2011.03.005" @default.
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