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• W2048829583 abstract "A better understanding of the antigen presentation pathways that lead to CD8(+) T cell recognition of HIV epitopes in vivo is needed to achieve better immune control of HIV replication. Here, we show that cross-presentation of very small amounts of HIV proteins from apoptotic infected CD4(+) T lymphocytes by dendritic cells to CD8(+) T cells is much more efficient than other known HIV presentation pathways, i.e., direct presentation of infectious virus or cross-presentation of defective virus. Unexpectedly, dendritic cells also take up actively antigens into endosomes from live infected CD4(+) T lymphocytes and cross-present them as efficiently as antigens derived from apoptotic infected cells. Moreover, live infected CD4(+) T cells costimulate cross-presenting dendritic cells in the process. Therefore, dendritic cells can present very small amounts of viral proteins from infected T cells either after apoptosis, which is frequent during HIV infection, or not. Thus, if HIV expression is transiently induced while costimulation is enhanced (for instance after IL-2 and IFNalpha immune therapy), this HIV antigen presentation pathway could be exploited to eradicate latently infected reservoirs, which are poorly recognized by patients' immune systems." @default.
• W2048829583 created "2016-06-24" @default.
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• W2048829583 date "2004-04-12" @default.
• W2048829583 modified "2023-10-01" @default.
• W2048829583 title "Dendritic cells cross-present HIV antigens from live as well as apoptotic infected CD4 ⁺ T lymphocytes" @default.
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• W2048829583 doi "https://doi.org/10.1073/pnas.0304860101" @default.
• W2048829583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/395928" @default.
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