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• W2048829599 abstract "TRALI is a serious complication of transfusion. WBC antibodies have been associated with TRALI. The importance of such antibodies for the transfusion of granulocytes is unknown.A patient with hematologic malignancy and neutropenia-associated pneumonitis received 2 units of granulocytes despite a positive serologic cross- match. She developed severe TRALI after the second transfusion.The recipient's serum was reactive with immobilized HLA class I antigens from donor cells in a glycoprotein-specific assay. With an absorption-elution technique, at least anti-HLA-A2 could be identified as one of the donor-reactive antibodies in the recipient's serum.Granulocyte-reactive antibodies are associated with TRALI in an alloimmunized patient receiving granulocyte transfusions. Performing a cross-match procedure may be helpful in preventing severe pulmonary reactions. Additional data are required to determine whether cross-matching as a regular practice in granulocyte transfusions would be beneficial for patients." @default.
• W2048829599 created "2016-06-24" @default.
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• W2048829599 date "2003-12-01" @default.
• W2048829599 modified "2023-10-15" @default.
• W2048829599 title "TRALI after the transfusion of cross-match-positive granulocytes" @default.
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• W2048829599 doi "https://doi.org/10.1111/j.0041-1132.2003.00568.x" @default.
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