FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048831569> ?p ?o ?g. }

• W2048831569 endingPage "395" @default.
• W2048831569 startingPage "381" @default.
• W2048831569 abstract "The ER is one of the most important folding compartments within the cell, as well as an intracellular Ca(2+) storage organelle and it contains a number of Ca(2+) regulated molecular chaperones responsible for the proper folding of glycosylated as well as non-glycosylated proteins. The luminal environment of the ER contains Ca(2+) which is involved in regulating chaperones such as calnexin and calreticulin, as well as apoptotic proteins caspase-12 and Bap31, which may play an important role in determining cellular sensitivity to ER stress and apoptosis. The ER quality control system consists of several molecular chaperones, including calnexin, that assist in properly folding proteins and transporting them through the ER as well as sensing misfolded proteins, attempting to refold them and if this is not possible, targeting them for degradation. Accumulation of misfolded protein in the ER leads to activation of genes responsible for the expression of ER chaperones. The UPR mechanism involves transcriptional activation of chaperones by the membrane-localized transcription factor ATF6, in conjunction with the ER membrane kinase IRE1, as well as translational repression of protein synthesis by another ER membrane kinase PERK. When accumulation of misfolded protein becomes toxic, apoptosis is triggered, potentially with IRE1 involved in signaling via caspase-12. Both the extrinsic and intrinsic apoptotic pathways appear to culminate in the activation of caspases and this results in the recruitment of mitochondria in an essential amplifying manner. Bap31 may direct pro-apoptotic crosstalk between the ER and the mitochondria via Ca(2+) in conjunction with caspase-12 and calnexin. Accordingly, ER stress and the resultant Ca(2+) release must be very carefully regulated because of their effects in virtually all areas of cell function." @default.
• W2048831569 created "2016-06-24" @default.
• W2048831569 creator A5052943656 @default.
• W2048831569 creator A5064011319 @default.
• W2048831569 date "2005-05-31" @default.
• W2048831569 modified "2023-09-25" @default.
• W2048831569 title "Endoplasmic reticulum quality control and apoptosis." @default.
• W2048831569 cites W1484949053 @default.
• W2048831569 cites W1492302205 @default.
• W2048831569 cites W1512178996 @default.
• W2048831569 cites W1522731616 @default.
• W2048831569 cites W1535426243 @default.
• W2048831569 cites W1546139069 @default.
• W2048831569 cites W1546951167 @default.
• W2048831569 cites W1571529930 @default.
• W2048831569 cites W1577397450 @default.
• W2048831569 cites W1586442162 @default.
• W2048831569 cites W15886477 @default.
• W2048831569 cites W1599277155 @default.
• W2048831569 cites W1607777232 @default.
• W2048831569 cites W164666323 @default.
• W2048831569 cites W1782545213 @default.
• W2048831569 cites W1804578161 @default.
• W2048831569 cites W1880554341 @default.
• W2048831569 cites W1905806846 @default.
• W2048831569 cites W1920963152 @default.
• W2048831569 cites W1964706050 @default.
• W2048831569 cites W1965440944 @default.
• W2048831569 cites W1967357725 @default.
• W2048831569 cites W1967912613 @default.
• W2048831569 cites W1968269700 @default.
• W2048831569 cites W1968659980 @default.
• W2048831569 cites W1969023905 @default.
• W2048831569 cites W1969666197 @default.
• W2048831569 cites W1970007744 @default.
• W2048831569 cites W1970090817 @default.
• W2048831569 cites W1973436922 @default.
• W2048831569 cites W1975153732 @default.
• W2048831569 cites W1976141746 @default.
• W2048831569 cites W197615574 @default.
• W2048831569 cites W1976405409 @default.
• W2048831569 cites W1977716370 @default.
• W2048831569 cites W1978559408 @default.
• W2048831569 cites W1979014608 @default.
• W2048831569 cites W1979733074 @default.
• W2048831569 cites W1979995768 @default.
• W2048831569 cites W1983416626 @default.
• W2048831569 cites W1984672567 @default.
• W2048831569 cites W1985271970 @default.
• W2048831569 cites W1985339713 @default.
• W2048831569 cites W1985868156 @default.
• W2048831569 cites W1986737010 @default.
• W2048831569 cites W1987785848 @default.
• W2048831569 cites W1987952787 @default.
• W2048831569 cites W1988740497 @default.
• W2048831569 cites W1991958238 @default.
• W2048831569 cites W1992864681 @default.
• W2048831569 cites W1993129198 @default.
• W2048831569 cites W1994947913 @default.
• W2048831569 cites W1996952569 @default.
• W2048831569 cites W1999349182 @default.
• W2048831569 cites W2000352412 @default.
• W2048831569 cites W2000962968 @default.
• W2048831569 cites W2002117041 @default.
• W2048831569 cites W2002208801 @default.
• W2048831569 cites W2004816473 @default.
• W2048831569 cites W2005953273 @default.
• W2048831569 cites W2006652614 @default.
• W2048831569 cites W2007057690 @default.
• W2048831569 cites W2008186920 @default.
• W2048831569 cites W2010083809 @default.
• W2048831569 cites W2010605892 @default.
• W2048831569 cites W2012922643 @default.
• W2048831569 cites W2013947447 @default.
• W2048831569 cites W2013993442 @default.
• W2048831569 cites W2014586657 @default.
• W2048831569 cites W2019083595 @default.
• W2048831569 cites W2023397454 @default.
• W2048831569 cites W2023680254 @default.
• W2048831569 cites W2023856040 @default.
• W2048831569 cites W2026357888 @default.
• W2048831569 cites W2028062152 @default.
• W2048831569 cites W2029797799 @default.
• W2048831569 cites W2030387038 @default.
• W2048831569 cites W2032702362 @default.
• W2048831569 cites W2032946509 @default.
• W2048831569 cites W2033260606 @default.
• W2048831569 cites W2033873142 @default.
• W2048831569 cites W2034213169 @default.
• W2048831569 cites W2034862605 @default.
• W2048831569 cites W2037174089 @default.
• W2048831569 cites W2037665471 @default.
• W2048831569 cites W2038118195 @default.
• W2048831569 cites W2039451567 @default.
• W2048831569 cites W2040485388 @default.
• W2048831569 cites W2042704408 @default.
• W2048831569 cites W2043305034 @default.
• W2048831569 cites W2046072178 @default.

• next