Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048832912> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2048832912 endingPage "48" @default.
- W2048832912 startingPage "S" @default.
- W2048832912 abstract "Inflammatory (Ly6Chi CCR2+) monocytes provide defense against infections but also contribute to autoimmune diseases and atherosclerosis. Monocytes originate from bone marrow and their entry into the bloodstream requires stimulation of CCR2 chemokine receptor by monocyte chemotactic protein-1 (MCP1). How monocyte emigration from bone marrow is triggered by remote infections remains unclear. We demonstrated that low concentrations of Toll-like receptor (TLR) ligands in the bloodstream drive CCR2-dependent emigration of monocytes from bone marrow. Bone marrow mesenchymal stem cells (MSCs) and their progeny, including CXC chemokine ligand (CXCL)12-abundant reticular (CAR) cells, rapidly expressed MCP1 in response to circulating TLR ligands or bacterial infection and induced monocyte trafficking into the bloodstream. Targeted deletion of MCP1 from MSCs impaired monocyte emigration from bone marrow. Our findings suggest that bone marrow MSCs and CAR cells respond to circulating microbial molecules and regulate bloodstream monocyte frequencies by secreting MCP1 in proximity to bone marrow vascular sinuses." @default.
- W2048832912 created "2016-06-24" @default.
- W2048832912 creator A5000385663 @default.
- W2048832912 creator A5018653096 @default.
- W2048832912 creator A5029930183 @default.
- W2048832912 creator A5042544807 @default.
- W2048832912 creator A5061419546 @default.
- W2048832912 creator A5063884387 @default.
- W2048832912 creator A5073048235 @default.
- W2048832912 creator A5078914737 @default.
- W2048832912 date "2014-05-01" @default.
- W2048832912 modified "2023-10-13" @default.
- W2048832912 title "182 Impaired NOD1 Function Induce Dysplasia in Helicobacter pylori Infected Stomach Through Wnt/β-Catenin Signaling" @default.
- W2048832912 doi "https://doi.org/10.1016/s0016-5085(14)60165-7" @default.
- W2048832912 hasPublicationYear "2014" @default.
- W2048832912 type Work @default.
- W2048832912 sameAs 2048832912 @default.
- W2048832912 citedByCount "0" @default.
- W2048832912 crossrefType "journal-article" @default.
- W2048832912 hasAuthorship W2048832912A5000385663 @default.
- W2048832912 hasAuthorship W2048832912A5018653096 @default.
- W2048832912 hasAuthorship W2048832912A5029930183 @default.
- W2048832912 hasAuthorship W2048832912A5042544807 @default.
- W2048832912 hasAuthorship W2048832912A5061419546 @default.
- W2048832912 hasAuthorship W2048832912A5063884387 @default.
- W2048832912 hasAuthorship W2048832912A5073048235 @default.
- W2048832912 hasAuthorship W2048832912A5078914737 @default.
- W2048832912 hasBestOaLocation W20488329121 @default.
- W2048832912 hasConcept C101666144 @default.
- W2048832912 hasConcept C12823836 @default.
- W2048832912 hasConcept C13373296 @default.
- W2048832912 hasConcept C198826908 @default.
- W2048832912 hasConcept C203014093 @default.
- W2048832912 hasConcept C206615009 @default.
- W2048832912 hasConcept C2776914184 @default.
- W2048832912 hasConcept C2780007613 @default.
- W2048832912 hasConcept C2781184567 @default.
- W2048832912 hasConcept C71924100 @default.
- W2048832912 hasConcept C86803240 @default.
- W2048832912 hasConcept C95444343 @default.
- W2048832912 hasConceptScore W2048832912C101666144 @default.
- W2048832912 hasConceptScore W2048832912C12823836 @default.
- W2048832912 hasConceptScore W2048832912C13373296 @default.
- W2048832912 hasConceptScore W2048832912C198826908 @default.
- W2048832912 hasConceptScore W2048832912C203014093 @default.
- W2048832912 hasConceptScore W2048832912C206615009 @default.
- W2048832912 hasConceptScore W2048832912C2776914184 @default.
- W2048832912 hasConceptScore W2048832912C2780007613 @default.
- W2048832912 hasConceptScore W2048832912C2781184567 @default.
- W2048832912 hasConceptScore W2048832912C71924100 @default.
- W2048832912 hasConceptScore W2048832912C86803240 @default.
- W2048832912 hasConceptScore W2048832912C95444343 @default.
- W2048832912 hasIssue "5" @default.
- W2048832912 hasLocation W20488329121 @default.
- W2048832912 hasOpenAccess W2048832912 @default.
- W2048832912 hasPrimaryLocation W20488329121 @default.
- W2048832912 hasRelatedWork W1989199068 @default.
- W2048832912 hasRelatedWork W2010472544 @default.
- W2048832912 hasRelatedWork W2069629865 @default.
- W2048832912 hasRelatedWork W2120094575 @default.
- W2048832912 hasRelatedWork W2135703618 @default.
- W2048832912 hasRelatedWork W2137876530 @default.
- W2048832912 hasRelatedWork W2776126594 @default.
- W2048832912 hasRelatedWork W332727961 @default.
- W2048832912 hasRelatedWork W4213343993 @default.
- W2048832912 hasRelatedWork W584440894 @default.
- W2048832912 hasVolume "146" @default.
- W2048832912 isParatext "false" @default.
- W2048832912 isRetracted "false" @default.
- W2048832912 magId "2048832912" @default.
- W2048832912 workType "article" @default.