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- W2048833556 abstract "We have studied the levels of phospholipids, triglycerides, cholesterol esters, and their fatty acid composition in serum for normal, castrated and estradiol treated rats. The sex hormones did not greatly affect the levels of the various lipid fractions which did not undergo great significant variations, under the different treatments. More evident variations occurred in the percent composition of fatty acid and in the content of the various saturated (SAT), unsaturated (UNSAT), essential (EFA) and non essential fatty acids (NEFA). We studied the most important ratios: EFA/NEFA; UNS/SAT; 16:016:1; 18:018:1, 18:218:3; 18:220:4. 16:016:1; 18:018:1 represent the Δ9 desaturase, one specific for palmitic, the other for stearic acid. 18:218:3 ratio is an index of the Δ6 desaturase activity: 18:220:4 ratio of Δ5 desaturase-elongase. Most changes were evident in triglycerides. We observed a different behaviour of the UNS/SAT and EFA/NEFA ratios in phospholipids and cholesterol esters, which may reflect either an effect of the sex hormones on the exchange of fatty acids between the same lipid fractions, or a redistribution of lipids among different tissues. Great variations were observed of the ratios 16:016:1; 18:018:1; 18:218:3; 18:220:4, which are ascribed a different effect of the sex hormones of Δ9, Δ6, Δ5 desaturases." @default.
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- W2048833556 date "2000-03-01" @default.
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- W2048833556 title "Fatty acid composition of phospholipids, triglycerides and cholesterol in serum of castrated and estradiol treated rats" @default.
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- W2048833556 doi "https://doi.org/10.1016/s0024-3205(00)00484-7" @default.
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