Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048836045> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2048836045 endingPage "125" @default.
- W2048836045 startingPage "118" @default.
- W2048836045 abstract "The relationship between metastatic cells in the spleen and bone marrow of tumor-bearing mice and the NK activity generated in vitro by cells obtained from these organs was investigated. EL-4 lymphoma and B16 melanoma cells injected intraperitoneally into syngeneic mice (10(6) cells/animal) killed the recipients in 16 days. These tumors had a different metastatic profile: EL-4 metastasized to the spleen and bone marrow while B16 did not. The number of metastatic cells was evaluated by plating spleen or bone-marrow cells of tumor-bearing mice in agarose cultures; in parallel, the ability of spleen and bone-marrow cells to generate NK activity in vitro was assessed. The presence of 10(5) EL-4 cells/10(6) spleen or bone-marrow cells correlated with a total lack of NK activity in these organs; in contrast, no decrease in NK activity was evident in the spleen or bone marrow of B16-bearing mice. The removal of metastatic EL-4 cells (by antibody and complement) from the spleen or bone marrow did not rescue the NK activity. The lack of NK activity in spleen and bone marrow colonized by metastatic cells was not due to induction of a suppressor cell in the host. Metastatic EL-4 cells appeared to have a direct and irreversible suppressive effect on the generation of NK activity by spleen or bone marrow. A possible cause-effect relationship between metastatic colonization of lymphoid organs and suppression of local NK activity is considered." @default.
- W2048836045 created "2016-06-24" @default.
- W2048836045 creator A5013089846 @default.
- W2048836045 creator A5074380743 @default.
- W2048836045 creator A5081192007 @default.
- W2048836045 date "1987-01-15" @default.
- W2048836045 modified "2023-09-25" @default.
- W2048836045 title "EL-4 metastases in spleen and bone marrow suppress the nk activity generated in these organs" @default.
- W2048836045 cites W1867460328 @default.
- W2048836045 cites W1899214849 @default.
- W2048836045 cites W1967157559 @default.
- W2048836045 cites W2006974353 @default.
- W2048836045 cites W2009011904 @default.
- W2048836045 cites W2014527286 @default.
- W2048836045 cites W2034713890 @default.
- W2048836045 cites W2043606640 @default.
- W2048836045 cites W2052218939 @default.
- W2048836045 cites W2056639654 @default.
- W2048836045 cites W2058250164 @default.
- W2048836045 cites W2061106536 @default.
- W2048836045 cites W2063820933 @default.
- W2048836045 cites W2076617145 @default.
- W2048836045 cites W2088768726 @default.
- W2048836045 cites W2088831236 @default.
- W2048836045 cites W2104971075 @default.
- W2048836045 cites W2115874670 @default.
- W2048836045 cites W2147787458 @default.
- W2048836045 cites W2210112194 @default.
- W2048836045 cites W2258889941 @default.
- W2048836045 cites W2764324821 @default.
- W2048836045 cites W4362040524 @default.
- W2048836045 cites W45306971 @default.
- W2048836045 doi "https://doi.org/10.1002/ijc.2910390121" @default.
- W2048836045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2947865" @default.
- W2048836045 hasPublicationYear "1987" @default.
- W2048836045 type Work @default.
- W2048836045 sameAs 2048836045 @default.
- W2048836045 citedByCount "10" @default.
- W2048836045 crossrefType "journal-article" @default.
- W2048836045 hasAuthorship W2048836045A5013089846 @default.
- W2048836045 hasAuthorship W2048836045A5074380743 @default.
- W2048836045 hasAuthorship W2048836045A5081192007 @default.
- W2048836045 hasConcept C142724271 @default.
- W2048836045 hasConcept C203014093 @default.
- W2048836045 hasConcept C2780007613 @default.
- W2048836045 hasConcept C2780931953 @default.
- W2048836045 hasConcept C502942594 @default.
- W2048836045 hasConcept C71924100 @default.
- W2048836045 hasConcept C86803240 @default.
- W2048836045 hasConceptScore W2048836045C142724271 @default.
- W2048836045 hasConceptScore W2048836045C203014093 @default.
- W2048836045 hasConceptScore W2048836045C2780007613 @default.
- W2048836045 hasConceptScore W2048836045C2780931953 @default.
- W2048836045 hasConceptScore W2048836045C502942594 @default.
- W2048836045 hasConceptScore W2048836045C71924100 @default.
- W2048836045 hasConceptScore W2048836045C86803240 @default.
- W2048836045 hasIssue "1" @default.
- W2048836045 hasLocation W20488360451 @default.
- W2048836045 hasLocation W20488360452 @default.
- W2048836045 hasOpenAccess W2048836045 @default.
- W2048836045 hasPrimaryLocation W20488360451 @default.
- W2048836045 hasRelatedWork W1542394131 @default.
- W2048836045 hasRelatedWork W1564182375 @default.
- W2048836045 hasRelatedWork W196940514 @default.
- W2048836045 hasRelatedWork W2042480534 @default.
- W2048836045 hasRelatedWork W2083940978 @default.
- W2048836045 hasRelatedWork W2093176879 @default.
- W2048836045 hasRelatedWork W2100328419 @default.
- W2048836045 hasRelatedWork W2381635637 @default.
- W2048836045 hasRelatedWork W2401724263 @default.
- W2048836045 hasRelatedWork W2416605036 @default.
- W2048836045 hasVolume "39" @default.
- W2048836045 isParatext "false" @default.
- W2048836045 isRetracted "false" @default.
- W2048836045 magId "2048836045" @default.
- W2048836045 workType "article" @default.