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- W2048837211 abstract "All organisms, even as they themselves age, must give rise to progeny that are young not only chronologically but also biochemically. Now, Hugo Aguilaniu, Thomas Nystrom (Goteborg University, Goteborg, Sweden), and colleagues show that budding yeast solves this problem by filtering oxidatively damaged proteins.Figure Carbonylated proteins (red) stay in the mother cell.The group set out to see if protein carbonylation, an irreversible form of oxidative damage, increased with age in budding yeast. It did, which immediately led to another question. “How,” asks Nystrom, “do the daughters come out fresh”?The daughters do, indeed, emerge with 3.6-fold less damage than their parents, and if the oxidative load is first boosted in the mother the ratio ratchets up to sixfold. This uneven segregation is dependent on the presence of Sir2p. This protein is required to prevent premature yeast aging, and was thought to operate in yeast solely by reducing the accumulation of toxic circles of rDNA.The mechanism of oxidative filtering remains unclear. It is dependent on actin, which suggests two possible scenarios. The actin may block nearly all mother proteins from entering the bud, so that the bud is built almost entirely from new protein synthesis. Or carbonylated proteins may be selectively retained in the mother by proteins that use actin as a scaffold. Nystrom is testing these possibilities and investigating whether mammalian stem cells might selectively off-load oxidized proteins into their differentiated progeny. ▪Reference:Aguilaniu, H., et al. 2003. Science. 10.1126/science.1080418. [PubMed]" @default.
- W2048837211 created "2016-06-24" @default.
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- W2048837211 date "2003-03-24" @default.
- W2048837211 modified "2023-10-18" @default.
- W2048837211 title "How old mothers can have young offspring" @default.
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- W2048837211 doi "https://doi.org/10.1083/jcb1607rr2" @default.
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