FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048844982> ?p ?o ?g. }

• W2048844982 endingPage "e66332" @default.
• W2048844982 startingPage "e66332" @default.
• W2048844982 abstract "Expression of optogenetic tools in surviving inner retinal neurons to impart retinal light sensitivity has been a new strategy for restoring vision after photoreceptor degeneration. One potential approach for restoring retinal light sensitivity after photoreceptor degeneration is to express optogenetic tools in retinal ganglion cells (RGCs). For this approach, restoration of ON and OFF center-surround receptive fields in RGCs, a key feature of visual information processing, may be important. A possible solution is to differentially express depolarizing and hyperpolarizing optogenetic tools, such as channelrhodopsin-2 and halorhodopsin, to the center and peripheral regions of the RGC dendritic field by using protein targeting motifs. Recombinant adeno-associated virus (rAAV) vectors have proven to be a powerful vehicle for in vitro and in vivo gene delivery, including in the retina. Therefore, the search for protein targeting motifs that can achieve rAAV-mediated subcellular targeted expression would be particularly valuable for developing therapeutic applications. In this study, we identified two protein motifs that are suitable for rAAV-mediated subcellular targeting for generating center-surround receptive fields while reducing the axonal expression in RGCs. Resulting morphological dendritic field and physiological response field by center-targeting were significantly smaller than those produced by surround-targeting. rAAV motif-mediated protein targeting could also be a valuable tool for studying physiological function and clinical applications in other areas of the central nervous system." @default.
• W2048844982 created "2016-06-24" @default.
• W2048844982 creator A5013280301 @default.
• W2048844982 creator A5044544424 @default.
• W2048844982 creator A5056156940 @default.
• W2048844982 creator A5066937673 @default.
• W2048844982 date "2013-06-14" @default.
• W2048844982 modified "2023-10-11" @default.
• W2048844982 title "rAAV-Mediated Subcellular Targeting of Optogenetic Tools in Retinal Ganglion Cells In Vivo" @default.
• W2048844982 cites W1560956408 @default.
• W2048844982 cites W1817006636 @default.
• W2048844982 cites W1920889222 @default.
• W2048844982 cites W1964709109 @default.
• W2048844982 cites W1965285506 @default.
• W2048844982 cites W1969650326 @default.
• W2048844982 cites W1972550857 @default.
• W2048844982 cites W1983219118 @default.
• W2048844982 cites W1988813033 @default.
• W2048844982 cites W1988990594 @default.
• W2048844982 cites W1999311112 @default.
• W2048844982 cites W2017787995 @default.
• W2048844982 cites W2022759417 @default.
• W2048844982 cites W2027846728 @default.
• W2048844982 cites W2032965800 @default.
• W2048844982 cites W2042334193 @default.
• W2048844982 cites W2042994165 @default.
• W2048844982 cites W2046297486 @default.
• W2048844982 cites W2047051831 @default.
• W2048844982 cites W2057222381 @default.
• W2048844982 cites W2057782586 @default.
• W2048844982 cites W2061614618 @default.
• W2048844982 cites W2065358689 @default.
• W2048844982 cites W2070691915 @default.
• W2048844982 cites W2079104378 @default.
• W2048844982 cites W2080633827 @default.
• W2048844982 cites W2088682369 @default.
• W2048844982 cites W2090907933 @default.
• W2048844982 cites W2097242525 @default.
• W2048844982 cites W2101567225 @default.
• W2048844982 cites W2108846059 @default.
• W2048844982 cites W2133147654 @default.
• W2048844982 cites W2136896522 @default.
• W2048844982 cites W2137222303 @default.
• W2048844982 cites W2150818788 @default.
• W2048844982 cites W2152853777 @default.
• W2048844982 cites W2158094776 @default.
• W2048844982 cites W2158310183 @default.
• W2048844982 cites W2165124201 @default.
• W2048844982 cites W2170576305 @default.
• W2048844982 cites W2212384750 @default.
• W2048844982 doi "https://doi.org/10.1371/journal.pone.0066332" @default.
• W2048844982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3683040" @default.
• W2048844982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23799092" @default.
• W2048844982 hasPublicationYear "2013" @default.
• W2048844982 type Work @default.
• W2048844982 sameAs 2048844982 @default.
• W2048844982 citedByCount "67" @default.
• W2048844982 countsByYear W20488449822014 @default.
• W2048844982 countsByYear W20488449822015 @default.
• W2048844982 countsByYear W20488449822016 @default.
• W2048844982 countsByYear W20488449822017 @default.
• W2048844982 countsByYear W20488449822018 @default.
• W2048844982 countsByYear W20488449822019 @default.
• W2048844982 countsByYear W20488449822020 @default.
• W2048844982 countsByYear W20488449822021 @default.
• W2048844982 countsByYear W20488449822022 @default.
• W2048844982 countsByYear W20488449822023 @default.
• W2048844982 crossrefType "journal-article" @default.
• W2048844982 hasAuthorship W2048844982A5013280301 @default.
• W2048844982 hasAuthorship W2048844982A5044544424 @default.
• W2048844982 hasAuthorship W2048844982A5056156940 @default.
• W2048844982 hasAuthorship W2048844982A5066937673 @default.
• W2048844982 hasBestOaLocation W20488449821 @default.
• W2048844982 hasConcept C169760540 @default.
• W2048844982 hasConcept C189542057 @default.
• W2048844982 hasConcept C19071747 @default.
• W2048844982 hasConcept C2777093970 @default.
• W2048844982 hasConcept C2780827179 @default.
• W2048844982 hasConcept C2781040256 @default.
• W2048844982 hasConcept C36890616 @default.
• W2048844982 hasConcept C37218471 @default.
• W2048844982 hasConcept C41625074 @default.
• W2048844982 hasConcept C50738837 @default.
• W2048844982 hasConcept C54355233 @default.
• W2048844982 hasConcept C55493867 @default.
• W2048844982 hasConcept C86803240 @default.
• W2048844982 hasConcept C95444343 @default.
• W2048844982 hasConceptScore W2048844982C169760540 @default.
• W2048844982 hasConceptScore W2048844982C189542057 @default.
• W2048844982 hasConceptScore W2048844982C19071747 @default.
• W2048844982 hasConceptScore W2048844982C2777093970 @default.
• W2048844982 hasConceptScore W2048844982C2780827179 @default.
• W2048844982 hasConceptScore W2048844982C2781040256 @default.
• W2048844982 hasConceptScore W2048844982C36890616 @default.
• W2048844982 hasConceptScore W2048844982C37218471 @default.
• W2048844982 hasConceptScore W2048844982C41625074 @default.
• W2048844982 hasConceptScore W2048844982C50738837 @default.
• W2048844982 hasConceptScore W2048844982C54355233 @default.

• next