Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048859636> ?p ?o ?g. }
- W2048859636 endingPage "165" @default.
- W2048859636 startingPage "145" @default.
- W2048859636 abstract "Cancer is a chronic disease and its pathogenesis is well correlated with infection and inflammation. Adenosine is a purine nucleoside, which is produced under metabolic stress like hypoxic conditions. Acute or chronic inflammatory conditions lead to the release of precursor adenine nucleotides (adenosine triphosphate (ATP), adenosien diphosphate (ADP) and adenosine monophosphate (AMP)) from cells, which are extracellularly catabolized into adenosine by extracellular ectonucleotidases, i.e., CD39 or nucleoside triphosphate dephosphorylase (NTPD) and CD73 or 5'-ectonucleotidase. It is now well-known that adenosine is secreted by cancer as well as immune cells during tumor pathogenesis under metabolic stress or hypoxia. Once adenosine is released into the extracellular environment, it exerts various immunomodulatory effects via adenosine receptors (A1, A2A, A2B, and A3) expressed on various immune cells (i.e., macrophages, myeloid-derived suppressor cells (MDSCs), natural killer (NK) cells, dendritic cells (DCs), T cells, regulatory T cell (Tregs), etc.), which play very important roles in the pathogenesis of cancer. This review is intended to summarize the role of inflammation and adenosine in the immunopathogenesis of tumor along with regulation of tumor-specific immune response and its modulation as an adjunct approach to tumor immunotherapy." @default.
- W2048859636 created "2016-06-24" @default.
- W2048859636 creator A5075490012 @default.
- W2048859636 date "2012-12-28" @default.
- W2048859636 modified "2023-10-15" @default.
- W2048859636 title "Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go?" @default.
- W2048859636 cites W1479956385 @default.
- W2048859636 cites W1486722793 @default.
- W2048859636 cites W1504084775 @default.
- W2048859636 cites W1513558382 @default.
- W2048859636 cites W1521212256 @default.
- W2048859636 cites W1522859339 @default.
- W2048859636 cites W1525984439 @default.
- W2048859636 cites W1534658079 @default.
- W2048859636 cites W1551486074 @default.
- W2048859636 cites W1575585006 @default.
- W2048859636 cites W1585754595 @default.
- W2048859636 cites W1590293337 @default.
- W2048859636 cites W1590952631 @default.
- W2048859636 cites W1600888997 @default.
- W2048859636 cites W161060649 @default.
- W2048859636 cites W1640854798 @default.
- W2048859636 cites W1644502582 @default.
- W2048859636 cites W1661544713 @default.
- W2048859636 cites W1678468169 @default.
- W2048859636 cites W1755638404 @default.
- W2048859636 cites W1925817305 @default.
- W2048859636 cites W1928151495 @default.
- W2048859636 cites W1946328238 @default.
- W2048859636 cites W1963809693 @default.
- W2048859636 cites W1964703707 @default.
- W2048859636 cites W1965037168 @default.
- W2048859636 cites W1967412131 @default.
- W2048859636 cites W1970027494 @default.
- W2048859636 cites W1971790974 @default.
- W2048859636 cites W1972308909 @default.
- W2048859636 cites W1972616341 @default.
- W2048859636 cites W1972771670 @default.
- W2048859636 cites W1977187462 @default.
- W2048859636 cites W1978762498 @default.
- W2048859636 cites W1981464756 @default.
- W2048859636 cites W1981552113 @default.
- W2048859636 cites W1982951034 @default.
- W2048859636 cites W1984543828 @default.
- W2048859636 cites W1984677655 @default.
- W2048859636 cites W1984942962 @default.
- W2048859636 cites W1985105495 @default.
- W2048859636 cites W1985407729 @default.
- W2048859636 cites W1985482500 @default.
- W2048859636 cites W1986349546 @default.
- W2048859636 cites W1986969648 @default.
- W2048859636 cites W1990113288 @default.
- W2048859636 cites W1990180666 @default.
- W2048859636 cites W1990227965 @default.
- W2048859636 cites W1991975288 @default.
- W2048859636 cites W1992457570 @default.
- W2048859636 cites W1994030928 @default.
- W2048859636 cites W1994440811 @default.
- W2048859636 cites W1995358920 @default.
- W2048859636 cites W1996123836 @default.
- W2048859636 cites W1996213381 @default.
- W2048859636 cites W1998551845 @default.
- W2048859636 cites W1999227421 @default.
- W2048859636 cites W2000115037 @default.
- W2048859636 cites W2000989410 @default.
- W2048859636 cites W2001445126 @default.
- W2048859636 cites W2002726823 @default.
- W2048859636 cites W2004150448 @default.
- W2048859636 cites W2004630197 @default.
- W2048859636 cites W2004708987 @default.
- W2048859636 cites W2006471464 @default.
- W2048859636 cites W2007087804 @default.
- W2048859636 cites W2007645309 @default.
- W2048859636 cites W2011846070 @default.
- W2048859636 cites W2012451630 @default.
- W2048859636 cites W2012461372 @default.
- W2048859636 cites W2015141049 @default.
- W2048859636 cites W2016762933 @default.
- W2048859636 cites W2017347652 @default.
- W2048859636 cites W2020818950 @default.
- W2048859636 cites W2021603971 @default.
- W2048859636 cites W2022056254 @default.
- W2048859636 cites W2023389612 @default.
- W2048859636 cites W2023699475 @default.
- W2048859636 cites W2026426963 @default.
- W2048859636 cites W2029123674 @default.
- W2048859636 cites W2030301553 @default.
- W2048859636 cites W2033877575 @default.
- W2048859636 cites W2034638444 @default.
- W2048859636 cites W2036205982 @default.
- W2048859636 cites W2036589433 @default.
- W2048859636 cites W2037489902 @default.
- W2048859636 cites W2039183048 @default.
- W2048859636 cites W2039198873 @default.
- W2048859636 cites W2040074251 @default.
- W2048859636 cites W2041679777 @default.
- W2048859636 cites W2042645266 @default.
- W2048859636 cites W2043029488 @default.