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- W2048865596 abstract "The apical small-conductance K+ channel plays an important role in renal K+ secretion, as evidenced by the presence of the extensive modulatory pathways. Figure 3 summarizes the current understanding of the mechanisms that modulate the apical small-conductance K+ channel. Stimulation of adenylate cyclase enhances channel activity and consequently K+ secretion. In contrast, increases in intracellular Ca2+ concentration and activation of Ca(2+)-dependent signal transduction pathways inhibit the K+ channel and thus decrease K+ secretion. The vasopressin-induced stimulation of K+ secretion in CCD results at least in part from cAMP-dependent signal transduction pathways. The Ca(2+)-dependent signal transduction pathway is responsible for modulatory coupling between Na+ pump turnover and apical K+ conductance when the Na+ pump is inhibited." @default.
- W2048865596 created "2016-06-24" @default.
- W2048865596 creator A5032533121 @default.
- W2048865596 date "1995-10-01" @default.
- W2048865596 modified "2023-10-15" @default.
- W2048865596 title "View of K+ secretion through the apical K channel of cortical collecting duct" @default.
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- W2048865596 doi "https://doi.org/10.1038/ki.1995.385" @default.
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