FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048875971> ?p ?o ?g. }

• W2048875971 endingPage "140" @default.
• W2048875971 startingPage "128" @default.
• W2048875971 abstract "Ataxia telangiectasia (A-T) is a human genetic disorder characterized by progressive cerebellar degeneration, hypersensitivity to ionizing radiation (IR), immunodeficiency, and high cancer risk. At the cellular level, IR sensitivity and increased frequency of spontaneous and IR-induced chromosomal breakage and rearrangements are the hallmarks of A-T. The ATM gene, mutated in this syndrome, has been cloned and codes for a protein sharing homology with DNA-PKcs, a protein kinase involved in DNA double-strand break (DSB) repair and DNA damage responses. The characteristics of the A-T cellular phenotypes and ATM gene suggest that ATM may play a role similar to that of DNA-PKcs in DSB repair and that there is a primary DNA repair defect in A-T cells. In the current study, the function of ATM in DNA DSB repair was evaluated in an in vitro system using two plasmids, carrying either an EcoRI-induced DSB within the lacZalpha gene or various endonuclease-induced DSB in the SupF suppressor tRNA gene. We found that the DSB repair efficiency in A-T nuclear extracts was comparable to, if not higher than, that in normal nuclear extracts. However, the repair fidelity in A-T nuclear extracts was decreased when repairing DSB with short 5' and 3' overhangs (<4 base pairs (bp)) or blunt ends, but not 5' 4-bp overhangs. Sequencing of the mutant plasmids revealed that deletions involving 1-6 nucleotide microhomologies were the major class of mutations in both A-T and normal extracts. However, the size of the deletions in plasmids from A-T nuclear extracts was larger than that from normal nuclear extracts. Expression of the ATM protein in A-T cells corrected the defect in DSB repair in A-T nuclear extracts. These results suggest that ATM plays a role in maintaining genomic stability by preventing the repair of DSB from an error-prone pathway." @default.
• W2048875971 created "2016-06-24" @default.
• W2048875971 creator A5004318102 @default.
• W2048875971 creator A5019315489 @default.
• W2048875971 creator A5031338708 @default.
• W2048875971 creator A5057856712 @default.
• W2048875971 creator A5091274044 @default.
• W2048875971 creator A5091516396 @default.
• W2048875971 date "2001-01-01" @default.
• W2048875971 modified "2023-10-03" @default.
• W2048875971 title "Expression of ATM in ataxia telangiectasia fibroblasts rescues defects in DNA double-strand break repair in nuclear extracts" @default.
• W2048875971 cites W1555218304 @default.
• W2048875971 cites W1618806168 @default.
• W2048875971 cites W1633875338 @default.
• W2048875971 cites W1739214237 @default.
• W2048875971 cites W1967264277 @default.
• W2048875971 cites W1967660527 @default.
• W2048875971 cites W1977284533 @default.
• W2048875971 cites W1981112371 @default.
• W2048875971 cites W1981950613 @default.
• W2048875971 cites W1986978393 @default.
• W2048875971 cites W1988267679 @default.
• W2048875971 cites W1992632955 @default.
• W2048875971 cites W1995284691 @default.
• W2048875971 cites W1999958793 @default.
• W2048875971 cites W2001764241 @default.
• W2048875971 cites W2028019289 @default.
• W2048875971 cites W2034489354 @default.
• W2048875971 cites W2038424689 @default.
• W2048875971 cites W2044770423 @default.
• W2048875971 cites W2052801384 @default.
• W2048875971 cites W2053827853 @default.
• W2048875971 cites W2062232773 @default.
• W2048875971 cites W2067028787 @default.
• W2048875971 cites W2075442531 @default.
• W2048875971 cites W2080859786 @default.
• W2048875971 cites W2082981258 @default.
• W2048875971 cites W2083456378 @default.
• W2048875971 cites W2085414209 @default.
• W2048875971 cites W2087110475 @default.
• W2048875971 cites W2090242035 @default.
• W2048875971 cites W2097316296 @default.
• W2048875971 cites W2107943906 @default.
• W2048875971 cites W2133539385 @default.
• W2048875971 cites W2135596463 @default.
• W2048875971 cites W2139964075 @default.
• W2048875971 cites W2143842681 @default.
• W2048875971 cites W2151968619 @default.
• W2048875971 cites W2159168998 @default.
• W2048875971 cites W2169830490 @default.
• W2048875971 cites W2209351655 @default.
• W2048875971 cites W2212226444 @default.
• W2048875971 doi "https://doi.org/10.1002/em.1020" @default.
• W2048875971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11246219" @default.
• W2048875971 hasPublicationYear "2001" @default.
• W2048875971 type Work @default.
• W2048875971 sameAs 2048875971 @default.
• W2048875971 citedByCount "15" @default.
• W2048875971 countsByYear W20488759712016 @default.
• W2048875971 countsByYear W20488759712018 @default.
• W2048875971 countsByYear W20488759712020 @default.
• W2048875971 countsByYear W20488759712022 @default.
• W2048875971 countsByYear W20488759712023 @default.
• W2048875971 crossrefType "journal-article" @default.
• W2048875971 hasAuthorship W2048875971A5004318102 @default.
• W2048875971 hasAuthorship W2048875971A5019315489 @default.
• W2048875971 hasAuthorship W2048875971A5031338708 @default.
• W2048875971 hasAuthorship W2048875971A5057856712 @default.
• W2048875971 hasAuthorship W2048875971A5091274044 @default.
• W2048875971 hasAuthorship W2048875971A5091516396 @default.
• W2048875971 hasConcept C104317684 @default.
• W2048875971 hasConcept C104451858 @default.
• W2048875971 hasConcept C134935766 @default.
• W2048875971 hasConcept C143425029 @default.
• W2048875971 hasConcept C145803527 @default.
• W2048875971 hasConcept C153911025 @default.
• W2048875971 hasConcept C22744801 @default.
• W2048875971 hasConcept C2777136964 @default.
• W2048875971 hasConcept C2779486608 @default.
• W2048875971 hasConcept C54355233 @default.
• W2048875971 hasConcept C552990157 @default.
• W2048875971 hasConcept C68748289 @default.
• W2048875971 hasConcept C86803240 @default.
• W2048875971 hasConceptScore W2048875971C104317684 @default.
• W2048875971 hasConceptScore W2048875971C104451858 @default.
• W2048875971 hasConceptScore W2048875971C134935766 @default.
• W2048875971 hasConceptScore W2048875971C143425029 @default.
• W2048875971 hasConceptScore W2048875971C145803527 @default.
• W2048875971 hasConceptScore W2048875971C153911025 @default.
• W2048875971 hasConceptScore W2048875971C22744801 @default.
• W2048875971 hasConceptScore W2048875971C2777136964 @default.
• W2048875971 hasConceptScore W2048875971C2779486608 @default.
• W2048875971 hasConceptScore W2048875971C54355233 @default.
• W2048875971 hasConceptScore W2048875971C552990157 @default.
• W2048875971 hasConceptScore W2048875971C68748289 @default.
• W2048875971 hasConceptScore W2048875971C86803240 @default.
• W2048875971 hasIssue "2" @default.
• W2048875971 hasLocation W20488759711 @default.

• next