Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048883485> ?p ?o ?g. }
- W2048883485 endingPage "376" @default.
- W2048883485 startingPage "363" @default.
- W2048883485 abstract "One strategy being evaluated for HIV-1 vaccine development is focusing immune responses towards neutralizing epitopes on the gp120 outer domain (OD) by removing the immunodominant, but non-neutralizing, inner domain. Previous OD constructs have not elicited strong neutralizing antibodies (nAbs). We constructed two immunogens, a monomeric gp120-OD and a trimeric gp120-OD×3, based on an M group consensus sequence (MCON6). Their biochemical and immunological properties were compared with intact gp120. Results indicated better preservation of critical neutralizing epitopes on gp120-OD×3. In contrast to previous studies, our immunogens induced potent, cross-reactive nAbs in rabbits. Although nAbs primarily targeted Tier 1 viruses, they exhibited significant breadth. Epitope mapping analyses indicated that nAbs primarily targeted conserved V3 loop elements. Although the potency and breadth of nAbs were similar for all three immunogens, nAb induction kinetics indicated that gp120-OD×3 was superior to gp120-OD, suggesting that gp120-OD×3 is a promising prototype for further gp120 OD-based immunogen development." @default.
- W2048883485 created "2016-06-24" @default.
- W2048883485 creator A5004036928 @default.
- W2048883485 creator A5038813665 @default.
- W2048883485 creator A5048701421 @default.
- W2048883485 creator A5056319434 @default.
- W2048883485 creator A5056602559 @default.
- W2048883485 creator A5071352515 @default.
- W2048883485 creator A5074665368 @default.
- W2048883485 creator A5076882237 @default.
- W2048883485 creator A5090240218 @default.
- W2048883485 date "2014-08-01" @default.
- W2048883485 modified "2023-09-27" @default.
- W2048883485 title "Eliciting neutralizing antibodies with gp120 outer domain constructs based on M-group consensus sequence" @default.
- W2048883485 cites W1482128944 @default.
- W2048883485 cites W1503866863 @default.
- W2048883485 cites W1521874564 @default.
- W2048883485 cites W1529883997 @default.
- W2048883485 cites W1534972788 @default.
- W2048883485 cites W1576634738 @default.
- W2048883485 cites W1607434342 @default.
- W2048883485 cites W1628484047 @default.
- W2048883485 cites W1794879226 @default.
- W2048883485 cites W1842798465 @default.
- W2048883485 cites W1971777539 @default.
- W2048883485 cites W1978512485 @default.
- W2048883485 cites W1992529182 @default.
- W2048883485 cites W1995355944 @default.
- W2048883485 cites W1999483871 @default.
- W2048883485 cites W2000551760 @default.
- W2048883485 cites W2000885937 @default.
- W2048883485 cites W2006712680 @default.
- W2048883485 cites W2008612546 @default.
- W2048883485 cites W2009857985 @default.
- W2048883485 cites W2012362118 @default.
- W2048883485 cites W2023273943 @default.
- W2048883485 cites W2028352208 @default.
- W2048883485 cites W2029135056 @default.
- W2048883485 cites W2033754329 @default.
- W2048883485 cites W2036018115 @default.
- W2048883485 cites W2046563994 @default.
- W2048883485 cites W2051715172 @default.
- W2048883485 cites W2052604124 @default.
- W2048883485 cites W2052937459 @default.
- W2048883485 cites W2061241401 @default.
- W2048883485 cites W2067107443 @default.
- W2048883485 cites W2068159204 @default.
- W2048883485 cites W2070086938 @default.
- W2048883485 cites W2071504541 @default.
- W2048883485 cites W2072974935 @default.
- W2048883485 cites W2077977162 @default.
- W2048883485 cites W2080089116 @default.
- W2048883485 cites W2083726777 @default.
- W2048883485 cites W2084015527 @default.
- W2048883485 cites W2085577978 @default.
- W2048883485 cites W2087179955 @default.
- W2048883485 cites W2090763940 @default.
- W2048883485 cites W2095678514 @default.
- W2048883485 cites W2095972686 @default.
- W2048883485 cites W2098781795 @default.
- W2048883485 cites W2099381548 @default.
- W2048883485 cites W2099823590 @default.
- W2048883485 cites W2100593780 @default.
- W2048883485 cites W2100953974 @default.
- W2048883485 cites W2102044579 @default.
- W2048883485 cites W2102548388 @default.
- W2048883485 cites W2102741739 @default.
- W2048883485 cites W2102900953 @default.
- W2048883485 cites W2107207807 @default.
- W2048883485 cites W2109115694 @default.
- W2048883485 cites W2110287237 @default.
- W2048883485 cites W2113236498 @default.
- W2048883485 cites W2118274231 @default.
- W2048883485 cites W2118820599 @default.
- W2048883485 cites W2124445678 @default.
- W2048883485 cites W2124935744 @default.
- W2048883485 cites W2129330996 @default.
- W2048883485 cites W2131692078 @default.
- W2048883485 cites W2131903471 @default.
- W2048883485 cites W2134312805 @default.
- W2048883485 cites W2134890041 @default.
- W2048883485 cites W2135151522 @default.
- W2048883485 cites W2139468467 @default.
- W2048883485 cites W2143572016 @default.
- W2048883485 cites W2146478787 @default.
- W2048883485 cites W2146704167 @default.
- W2048883485 cites W2150786008 @default.
- W2048883485 cites W2153163225 @default.
- W2048883485 cites W2155228203 @default.
- W2048883485 cites W2171536421 @default.
- W2048883485 cites W2177434887 @default.
- W2048883485 cites W4248734872 @default.
- W2048883485 doi "https://doi.org/10.1016/j.virol.2014.06.006" @default.
- W2048883485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4125429" @default.
- W2048883485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25046154" @default.
- W2048883485 hasPublicationYear "2014" @default.
- W2048883485 type Work @default.
- W2048883485 sameAs 2048883485 @default.