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- W2048887646 abstract "Changes in the expression of the nitric oxide synthase isoforms (NOS) have been implicated in age-related neurodegeneration, although mechanisms responsible for specific differences such as reduced cognitive and motor functions are not well understood. Immunohistochemical examination of the age-dependent NOS-I and NOS-II expression in aging rats at 3, 12, 24, 36 months of age as well as in 36 months old rats who spent their last 3 months in an enriched environment, revealed a significant decrease in NOS-I expression with aging. In contrast, NOS-II increased at 36 months. Old rats kept under enriched environmental conditions, however, showed strongly reduced NOS-II expression. These results indicate that both NOS-I and II may contribute to age-related degenerative processes, but in contrast to NOS-I the age-dependent changes of NOS-II are reduced or even reversed by stimulating environmental conditions." @default.
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- W2048887646 date "2002-01-01" @default.
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- W2048887646 title "In contrast to neuronal NOS-I, the inducible NOS-II expression in aging brains is modified by enriched environmental conditions" @default.
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- W2048887646 doi "https://doi.org/10.1078/0940-2993-00220" @default.
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