Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048888932> ?p ?o ?g. }
- W2048888932 endingPage "139" @default.
- W2048888932 startingPage "128" @default.
- W2048888932 abstract "Murine Foxp3(+) Treg have recently been shown to express T-bet, a transcription factor characteristic of Th1 effector cells. A human Treg phenotype equivalent has not been reported. Here, we show that naïve human CD4(+) T cells incubated with low numbers of CD40-activated allogeneic B cells preferentially differentiate into alloantigen-specific CD4(hi) CD25(hi) Treg. These differentiated cells potently suppress effector T-cell responses and express T-bet, IFN-γ, and CXCR3, the features of Th1 effector cells. In contrast, co-culture of naïve CD4(+) T cells with high numbers of allogeneic B cells results in CD4(+) CD25(+) T cells that promote, rather than inhibit, effector T-cell responses, demonstrating the plasticity of CD4(+) T-cell differentiation in response to alloantigen-presenting B cells. The optimal accumulation of CD4(hi) CD25(hi) Treg induced using higher T cell:B cell co-culture ratios was dependent on the expression of T-bet and endogenously produced IFN-γ. Induction of Treg-mediated suppression function in the Treg population was not. As CXCR3 confers the preferential trafficking of T cells to tissue sites of IFN-γ, these human Th1-like Treg might be useful for modulating pathological Th1 effector responses, such as that occurring during graft-versus-host disease or graft rejection." @default.
- W2048888932 created "2016-06-24" @default.
- W2048888932 creator A5006943321 @default.
- W2048888932 creator A5007945942 @default.
- W2048888932 creator A5031397502 @default.
- W2048888932 creator A5033801352 @default.
- W2048888932 creator A5042355254 @default.
- W2048888932 creator A5049563242 @default.
- W2048888932 creator A5063458527 @default.
- W2048888932 creator A5075713847 @default.
- W2048888932 creator A5077617287 @default.
- W2048888932 date "2010-12-01" @default.
- W2048888932 modified "2023-10-17" @default.
- W2048888932 title "Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-γ- and T-bet-dependent pathway" @default.
- W2048888932 cites W1512851684 @default.
- W2048888932 cites W1589895816 @default.
- W2048888932 cites W1936243145 @default.
- W2048888932 cites W1971613814 @default.
- W2048888932 cites W1971984434 @default.
- W2048888932 cites W1979876556 @default.
- W2048888932 cites W1980888912 @default.
- W2048888932 cites W1987735044 @default.
- W2048888932 cites W1996378082 @default.
- W2048888932 cites W1997058116 @default.
- W2048888932 cites W1999951520 @default.
- W2048888932 cites W2001191688 @default.
- W2048888932 cites W2007466030 @default.
- W2048888932 cites W2011754426 @default.
- W2048888932 cites W2014781888 @default.
- W2048888932 cites W2014895337 @default.
- W2048888932 cites W2028475115 @default.
- W2048888932 cites W2036217777 @default.
- W2048888932 cites W2059012075 @default.
- W2048888932 cites W2063579960 @default.
- W2048888932 cites W2077297620 @default.
- W2048888932 cites W2080773387 @default.
- W2048888932 cites W2080935386 @default.
- W2048888932 cites W2084091282 @default.
- W2048888932 cites W2087035851 @default.
- W2048888932 cites W2088258412 @default.
- W2048888932 cites W2090831287 @default.
- W2048888932 cites W2091013171 @default.
- W2048888932 cites W2093011834 @default.
- W2048888932 cites W2096890213 @default.
- W2048888932 cites W2100699905 @default.
- W2048888932 cites W2102650038 @default.
- W2048888932 cites W2104087345 @default.
- W2048888932 cites W2110491264 @default.
- W2048888932 cites W2116706483 @default.
- W2048888932 cites W2124858864 @default.
- W2048888932 cites W2128475635 @default.
- W2048888932 cites W2146448606 @default.
- W2048888932 cites W2152642587 @default.
- W2048888932 cites W2155202717 @default.
- W2048888932 cites W2156716608 @default.
- W2048888932 cites W2157800695 @default.
- W2048888932 cites W4313422304 @default.
- W2048888932 cites W9925338 @default.
- W2048888932 doi "https://doi.org/10.1002/eji.201040724" @default.
- W2048888932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21182084" @default.
- W2048888932 hasPublicationYear "2010" @default.
- W2048888932 type Work @default.
- W2048888932 sameAs 2048888932 @default.
- W2048888932 citedByCount "40" @default.
- W2048888932 countsByYear W20488889322012 @default.
- W2048888932 countsByYear W20488889322013 @default.
- W2048888932 countsByYear W20488889322014 @default.
- W2048888932 countsByYear W20488889322015 @default.
- W2048888932 countsByYear W20488889322016 @default.
- W2048888932 countsByYear W20488889322017 @default.
- W2048888932 countsByYear W20488889322018 @default.
- W2048888932 countsByYear W20488889322019 @default.
- W2048888932 countsByYear W20488889322020 @default.
- W2048888932 countsByYear W20488889322021 @default.
- W2048888932 countsByYear W20488889322022 @default.
- W2048888932 countsByYear W20488889322023 @default.
- W2048888932 crossrefType "journal-article" @default.
- W2048888932 hasAuthorship W2048888932A5006943321 @default.
- W2048888932 hasAuthorship W2048888932A5007945942 @default.
- W2048888932 hasAuthorship W2048888932A5031397502 @default.
- W2048888932 hasAuthorship W2048888932A5033801352 @default.
- W2048888932 hasAuthorship W2048888932A5042355254 @default.
- W2048888932 hasAuthorship W2048888932A5049563242 @default.
- W2048888932 hasAuthorship W2048888932A5063458527 @default.
- W2048888932 hasAuthorship W2048888932A5075713847 @default.
- W2048888932 hasAuthorship W2048888932A5077617287 @default.
- W2048888932 hasBestOaLocation W20488889321 @default.
- W2048888932 hasConcept C12823836 @default.
- W2048888932 hasConcept C129374314 @default.
- W2048888932 hasConcept C13373296 @default.
- W2048888932 hasConcept C153911025 @default.
- W2048888932 hasConcept C154317977 @default.
- W2048888932 hasConcept C202751555 @default.
- W2048888932 hasConcept C203014093 @default.
- W2048888932 hasConcept C25532541 @default.
- W2048888932 hasConcept C2776090121 @default.
- W2048888932 hasConcept C2779727006 @default.
- W2048888932 hasConcept C2908647359 @default.